mortality/aging
• half of mice do not survive beyond the first week after birth
• mice suffer sudden deaths with few mice reaching adulthood
• mice often died the day after epileptic episode
|
nervous system
• with tail curling, back hunching, rhythmic twitching and rolling behaviors
|
• reduced cell density at P0
• however, brain size and cortex thickness are normal
|
• mild disorganization in the cerebral cortex
|
behavior/neurological
• with tail curling, back hunching, rhythmic twitching and rolling behaviors
|
growth/size/body
cellular