Phenotypes associated with this allele

• Allele Symbol: Rnf122^em1Caox
• Allele Name: endonuclease-mediated mutation 1, Xuetao Cao
• Allele ID: MGI:7647313
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf122^em1Caox/Rnf122^em1Caox	involves: C57BL/6J	MGI:7647314

Genotype
MGI:7647314

hm1

• Allelic Composition: Rnf122^em1Caox/Rnf122^em1Caox
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:344769 )

• prolonged survival and reduced inflammation following infection with VSV

immune system

immune system phenotype ( J:344769 )

N • frequencies of T cells, natural killer cells, B cells, dendritic cells, neutrophils, and F4/80+CD11b+ macrophages in the spleen are similar to wild-type controls

N • no significant difference in proportion of peritoneal macrophages or generation of bone marrow derived macrophages and conventional bone marrow derived dendritic cells

increased circulating interferon-alpha level ( J:344769 )

• following infection with VSV

increased circulating interferon-beta level ( J:344769 )

• following infection with VSV

increased circulating interleukin-6 level ( J:344769 )

• following infection with VSV

increased interferon-alpha secretion ( J:344769 )

• in macrophages and MEFs after infection with RNA virus (VSV and SeV) but not infection with DNA virus or a different RNA virus (encephalomyocarditis virus)

increased interferon-beta secretion ( J:344769 )

• increase in the expression and secretion of IFNB in macrophages after infection with RNA virus and transfection of poly(I:C)

increased interleukin-6 secretion ( J:344769 )

• in macrophages and MEFs after infection with RNA virus (VSV and SeV) but not infection with DNA virus or a different RNA virus (encephalomyocarditis virus)

increased tumor necrosis factor secretion ( J:344769 )

• in macrophages and MEFs after infection with RNA virus (VSV and SeV) but not infection with DNA virus or a different RNA virus (encephalomyocarditis virus)

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:344769 )

• prolonged survival and reduced inflammation following infection with VSV

homeostasis/metabolism

increased circulating interferon-alpha level ( J:344769 )

• following infection with VSV

increased circulating interferon-beta level ( J:344769 )

• following infection with VSV

increased circulating interleukin-6 level ( J:344769 )

• following infection with VSV