Phenotypes associated with this allele

• Allele Symbol: Rnd2^tm1.1Fgu
• Allele Name: targeted mutation 1.1, Francois Guillemot
• Allele ID: MGI:7647328
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rnd2^tm1.1Fgu/Rnd2^tm1.1Fgu	Not Specified	MGI:7657820

Genotype
MGI:7657820

cn1

• Allelic Composition: Rnd2^tm1.1Fgu/Rnd2^tm1.1Fgu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:344858 )

• at 21 days after viral cre injection, apoptosis of newborn dentate granule neurons is increased

• however, when viral cre injection is done at P0, no increase in apoptosis is seen

abnormal cerebellar granule cell migration ( J:344858 )

• following viral cre injection, newborn neurons with loss of expression migrate farther into the granule cell layer

abnormal hippocampus neuron morphology ( J:344858 )

• at 14 and 21 days post viral cre injection, the number of newborn dentate granule neurons is reduced

• following viral cre injection, neurons with loss of expression have larger cell bodies and longer and more branched dendrites

• viral cre expression at 3 weeks after birth, showed loss of neurons but normal positioning

• viral cre expression at 28 and 31 days, but not at 56 or 0 days, of age led to impaired survival of newborn neurons

• viral cre injection at P0 does not increase the size of the cell body

abnormal dendrite arborization pattern ( J:344858 )

• following viral cre injection, neurons with loss of expression have longer and more branched dendrites

• however, no difference in spine density is seen

• cre injection at P0 also results in increased dendritic length and node number at 21 days and 12 weeks post injection

abnormal action potential ( J:344858 )

• after viral cre induced deletion, action potential thresholds are increased, amplitudes are smaller, and maximal frequencies tend to be reduced

behavior/neurological

behavior/neurological phenotype ( J:344858 )

N • following injection of adults with cre to delete expression in adult-born dentate granule neurons, no defects in spatial memory, contextual fear discrimination, or depression-like behavior are seen

increased anxiety-related response ( J:344858 )

• in an elevated plus maze, mice with viral cre-induced loss of expression in adult-born neurons spend less time in the open arms even at 10 weeks after injection of cre

• however, time spent in the center of an open field is similar to controls

• viral cre injection at P0 did not result in increased anxiety-related behavior

cellular

increased neuron apoptosis ( J:344858 )

• at 21 days after viral cre injection, apoptosis of newborn dentate granule neurons is increased

• however, when viral cre injection is done at P0, no increase in apoptosis is seen

abnormal cerebellar granule cell migration ( J:344858 )

• following viral cre injection, newborn neurons with loss of expression migrate farther into the granule cell layer