Phenotypes associated with this allele

• Allele Symbol: Il31^tm1.1Snak
• Allele Name: targeted mutation 1.1, Susumu Nakae
• Allele ID: MGI:7647341
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il31^tm1.1Snak/Il31^tm1.1Snak	B6N(Cg)-Il31^tm1.1Snak	MGI:7660771

Genotype
MGI:7660771

hm1

• Allelic Composition: Il31^tm1.1Snak/Il31^tm1.1Snak
• Genetic Background: B6N(Cg)-Il31^tm1.1Snak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

decreased pruritus ( J:263831 )

• mice display reduced scratching frequency and duration in FITC- and/or DNFB-induced contact hypersensitivity (CHS)

immune system

immune system phenotype ( J:263831 )

N • mice show no differences in the proportions of immune cells in the thymus, lymph nodes, spleen and bone marrow relative to wild-type controls and appear grossly normal under SPF conditions

N • mice exhibit normal migration and maturation of skin dendritic cells and induction of hapten-specific T cells in the sensitization phase of FITC-induced contact hypersensitivity (CHS), and normal induction of local skin inflammation in the elicitation phase of FITC- and DNFB-induced CHS; after FITC challenge, serum levels of FITC-specific IgG subsets and total IgE show a similar increase relative to wild-type controls