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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ormdl1em1Pdra
endonuclease-mediated mutation 1, Petr Draber
MGI:7647342
Summary 4 genotypes


Genotype
MGI:7657402
hm1
Allelic
Composition		 Ormdl1em1Pdra/Ormdl1em1Pdra
Genetic
Background		 C57BL/6J-Ormdl1em1Pdra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ormdl1em1Pdra mutation (0 available); any Ormdl1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:349248 )
N
• high-affinity IgE receptor-mediated degranulation and calcium response of bone marrow-derived mast cells following activation with antigen is similar to the response seen in antigen-activated wild-type mast cells and total ceramide levels in bone marrow-derived mast cells are unchanged
• mast cells do not vary phenotypically from wild-type mast cells




Genotype
MGI:7657413
cx2
Allelic
Composition		 Ormdl1em1Pdra/Ormdl1em1Pdra
Ormdl2em1Pdra/Ormdl2em1Pdra
Genetic
Background		 C57BL/6-Ormdl1em1Pdra Ormdl2em1Pdra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ormdl1em1Pdra mutation (0 available); any Ormdl1 mutation (15 available)
Ormdl2em1Pdra mutation (0 available); any Ormdl2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:349248 )
N
• high-affinity IgE receptor-mediated degranulation and calcium response of bone marrow-derived mast cells following activation with antigen is similar to the response seen in antigen-activated wild-type mast cells and total ceramide levels in bone marrow-derived mast cells are unchanged
• mast cells do not vary phenotypically from wild-type mast cells




Genotype
MGI:7657417
cx3
Allelic
Composition		 Ormdl1em1Pdra/Ormdl1em1Pdra
Ormdl2em1Pdra/Ormdl2em1Pdra
Ormdl3em1Pdra/Ormdl3em1Pdra
Genetic
Background		 C57BL/6-Ormdl1em1Pdra Ormdl2em1Pdra Ormdl3em1Pdra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ormdl1em1Pdra mutation (0 available); any Ormdl1 mutation (15 available)
Ormdl2em1Pdra mutation (0 available); any Ormdl2 mutation (9 available)
Ormdl3em1Pdra mutation (0 available); any Ormdl3 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:349248 )
• no homozygous mice are obtained




Genotype
MGI:7657415
cx4
Allelic
Composition		 Ormdl1em1Pdra/Ormdl1em1Pdra
Ormdl3em1Pdra/Ormdl3em1Pdra
Genetic
Background		 C57BL/6-Ormdl1em1Pdra Ormdl3em1Pdra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ormdl1em1Pdra mutation (0 available); any Ormdl1 mutation (15 available)
Ormdl3em1Pdra mutation (0 available); any Ormdl3 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:349248 )
decreased body weight ( J:349248 )

hematopoietic system
abnormal mast cell physiology ( J:349248 )
• high-affinity IgE receptor-mediated calcium response of bone marrow-derived mast cells following activation with antigen is increased compared to the response seen in antigen-activated wild-type mast cells, without a corresponding increase in degranulation

homeostasis/metabolism
increased ceramide level ( J:349248 )
• concentrations of sphinganine (C18:0) and sphingosine (C18:1) and total ceramide levels, as well as individual long- and very long-chain ceramide species, are increased in bone marrow-derived mast cells
increased sphingosine level ( J:349248 )
• concentration of sphingosine (C18:1) is increased in bone marrow-derived mast cells

immune system
abnormal mast cell physiology ( J:349248 )
• high-affinity IgE receptor-mediated calcium response of bone marrow-derived mast cells following activation with antigen is increased compared to the response seen in antigen-activated wild-type mast cells, without a corresponding increase in degranulation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/15/2024
MGI 6.24 		The Jackson Laboratory