About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Phox2bem3(cre)Heno
endonuclease-mediated mutation 3, Hideki Enomoto
MGI:7657398
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Phox2bem3(cre)Heno/Phox2b+ involves: 129 * C57BL/6 * C57BL/6N * DBA MGI:7736348
cn2
 		Pcgf1tm1.1Hko/Pcgf1tm1.1Hko
Phox2bem3(cre)Heno/Phox2b+ 		involves: 129 * C57BL/6 * C57BL/6N * DBA MGI:7736341


Genotype
MGI:7736348
ht1
Allelic
Composition		 Phox2bem3(cre)Heno/Phox2b+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2bem3(cre)Heno mutation (0 available); any Phox2b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:344865 )
• slight growth retardation at 3 and 8 weeks of age




Genotype
MGI:7736341
cn2
Allelic
Composition		 Pcgf1tm1.1Hko/Pcgf1tm1.1Hko
Phox2bem3(cre)Heno/Phox2b+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcgf1tm1.1Hko mutation (1 available); any Pcgf1 mutation (21 available)
Phox2bem3(cre)Heno mutation (0 available); any Phox2b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:344865 )
• only half of mutants survive to adulthood

growth/size/body
decreased body size ( J:344865 )
• at 3 weeks of age
postnatal growth retardation ( J:344865 )
• at 3 weeks of age but catch up to controls (mice carrying just the recombinase allele) by 8 weeks of age

digestive/alimentary system
abnormal feces composition ( J:344865 )
• lighter and drier feces
abnormal colon morphology ( J:344865 )
• decrease in the number of the somatostatin-expressing neurons in the proximal colon
• increase in the number of calbindin-expressing neurons in the proximal colon
abnormal ileum morphology ( J:344865 )
• decrease in the number of the somatostatin-expressing neurons in the ileum
abnormal jejunum morphology ( J:344865 )
• decrease in the number of the somatostatin-expressing neurons in the jejunum
abnormal intestinal transit time ( J:344865 )
• increased total gastrointestinal transit time

nervous system
decreased neuron number ( J:344865 )
• decrease in the number of the somatostatin-expressing neurons in the ileum, jejunum, and proximal colon
increased neuron number ( J:344865 )
• increase in the number of calbindin-expressing neurons in the proximal colon




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory