Phenotypes associated with this allele

• Allele Symbol: Ifrd2^tm1.1Lah
• Allele Name: targeted mutation 1.1, Lukas A Huber
• Allele ID: MGI:7657419
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifrd2^tm1.1Lah/Ifrd2^tm1.1Lah	B6.129-Ifrd2^tm1.1Lah	MGI:7657425
cx2	Ifrd1^tm1Lah/Ifrd1^tm1Lah Ifrd2^tm1.1Lah/Ifrd2^tm1.1Lah	involves: 129 * 129P2/OlaHsd * C57BL/6J	MGI:7657422

Genotype
MGI:7657425

hm1

• Allelic Composition: Ifrd2^tm1.1Lah/Ifrd2^tm1.1Lah
• Genetic Background: B6.129-Ifrd2^tm1.1Lah

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:344868 )

♂ • lighter than controls

adipose tissue

decreased abdominal adipose tissue amount ( J:344868 )

♂ • decrease in abdominal fat content and size

decreased total body fat amount ( J:344868 )

♂ • leaner compared to controls

abnormal white fat cell differentation ( J:344868 )

♂ • cells from inguinal white adipose tissue display reduced differentiation in culture

cellular

abnormal white fat cell differentation ( J:344868 )

♂ • cells from inguinal white adipose tissue display reduced differentiation in culture

Genotype
MGI:7657422

cx2

• Allelic Composition: Ifrd1^tm1Lah/Ifrd1^tm1Lah; Ifrd2^tm1.1Lah/Ifrd2^tm1.1Lah
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6J

growth/size/body

increased lean body mass ( J:344868 )

♂ • percentage of lean mass is 92 +/- 3.14% compared to 60 +/- 4.6% in wild-type controls

slow postnatal weight gain ( J:344868 )

• both males and females fail to gain weight, starting during weaning

• weights are similar to controls at birth

• at 10 weeks of age body weights are 30% lower than controls and later this difference increases up to 44.9%

• food intake and activity are identical to controls and no differences are seen in respiratory exchange ratios

decreased susceptibility to weight gain ( J:344868 )

♂ • gain less weight on a high fat diet at 1, 2, and 3 weeks on the diet

♂ • difference in weight gain is detectable after 1 week on a high fat diet even though no significant difference in food intake is seen

adipose tissue

decreased abdominal adipose tissue amount ( J:344868 )

♂ • decreased in content and size

decreased total body fat amount ( J:344868 )

♂ • at 6 months of age, percentage of fat is 6 +/- 3% of total body mass compared to 37.7 +/- 4% in wild-type controls

abnormal white fat cell differentation ( J:344868 )

♂ • cells from inguinal white adipose tissue display reduced differentiation in culture

digestive/alimentary system

abnormal feces composition ( J:344868 )

♂ • increase in the amount of free fatty acids in the feces when on a high fat diet

♂ • energy content of dried feces is significantly increased

cellular

abnormal white fat cell differentation ( J:344868 )

♂ • cells from inguinal white adipose tissue display reduced differentiation in culture