About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc22a18tm1Tgot
targeted mutation 1, Takanari Gotoda
MGI:7657433
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc22a18tm1Tgot/Slc22a18tm1Tgot B6.Cg-Slc22a18tm1Tgot MGI:7657454
cx2
 		Lepob/Lepob
Slc22a18tm1Tgot/Slc22a18tm1Tgot 		involves: C57BL/6 MGI:7657458


Genotype
MGI:7657454
hm1
Allelic
Composition		 Slc22a18tm1Tgot/Slc22a18tm1Tgot
Genetic
Background		 B6.Cg-Slc22a18tm1Tgot
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc22a18tm1Tgot mutation (0 available); any Slc22a18 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased liver triglyceride level ( J:349247 )
• under refeeding conditions after fasting, hepatic triglyceride content is reduced

homeostasis/metabolism
decreased liver triglyceride level ( J:349247 )
• under refeeding conditions after fasting, hepatic triglyceride content is reduced

growth/size/body
growth/size/body region phenotype ( J:349247 )
N
• mice show normal growth, food intake, and organ weight




Genotype
MGI:7657458
cx2
Allelic
Composition		 Lepob/Lepob
Slc22a18tm1Tgot/Slc22a18tm1Tgot
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation (5 available); any Lep mutation (21 available)
Slc22a18tm1Tgot mutation (0 available); any Slc22a18 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
abnormal epididymal fat pad morphology ( J:349247 )
• mice show reduced epididymal fat mass compared to single Leprob homozygotes

liver/biliary system
decreased liver weight ( J:349247 )
• mice tend to show lower liver weight than single Leprob homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory