Phenotypes associated with this allele

• Allele Symbol: Trim66^em1Emr
• Allele Name: endonuclease-mediated mutation 1, EMBL Rome
• Allele ID: MGI:7657542
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim66^em1Emr/Trim66^em1Emr	FVB/NCrl-Trim66^em1Emr	MGI:7657546

Genotype
MGI:7657546

hm1

• Allelic Composition: Trim66^em1Emr/Trim66^em1Emr
• Genetic Background: FVB/NCrl-Trim66^em1Emr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

paternal effect ( J:349240 )

♂ • pups sired by homozygous males mated to wild-type females are on average 6.8% heavier than wild-type pups at birth, while no difference in weight for pups born from homozygous mothers bred with wild-type males is seen, indicating a paternal effect on intrauterine overgrowth of offspring

♂ • pups sired by homozygous males mated to homozygous females are heavier than wild-type pups at birth

♂ • the paternal effect overweight phenotype at birth does not persist until weaning

♂ • however, no differences in the size of litters produced by homozygous males and females are seen

mortality/aging

prenatal lethality, incomplete penetrance ( J:349240 )

• mating of homozygous males with homozygous females results in litters with fewer pups at birth, indicating partial penetrance of prenatal lethality

reproductive system

reproductive system phenotype ( J:349240 )

♂N • males exhibit normal testis weight and morphology, and normal sperm morphology, count, motility, and sperm fertilization efficiency in IVF

decreased litter size ( J:349240 )

• mating of homozygous males with homozygous females results in litters with fewer pups at birth, indicating partial penetrance of embryonic lethality

• however, no differences are seen in the size of litters produced by homozygous males and females that are mated with wild-type mice