All Phenotypes Ctps1<tm1c(KOMP)Wtsi> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd8a-cre)1Itan/0
Genetic Background	B6(129S4)-Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd8a-cre)1Itan

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctps1^{tm1c(KOMP)Wtsi} mutation (0 available); any Ctps1 mutation (46 available)
Tg(Cd8a-cre)1Itan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:348981 )

• upon activation with anti-CD3/CD28, CD8+ T cells from the spleen fail to proliferate leading to an effector memory CD8+ T cell impairment

• addition of cytidine to the culture medium during the activation rescues the proliferation defect of the CD8+ T cells

• however, no phenotypic differences are seen in the thymus and spleen, and no abnormalities are detected in blood, spleen cellularity and cell type composition

immune system

decreased T cell proliferation ( J:348981 )

• upon activation with anti-CD3/CD28, CD8+ T cells from the spleen fail to proliferate leading to an effector memory CD8+ T cell impairment

• addition of cytidine to the culture medium during the activation rescues the proliferation defect of the CD8+ T cells

• however, no phenotypic differences are seen in the thymus and spleen, and no abnormalities are detected in blood, spleen cellularity and cell type composition

cellular

decreased T cell proliferation ( J:348981 )

• upon activation with anti-CD3/CD28, CD8+ T cells from the spleen fail to proliferate leading to an effector memory CD8+ T cell impairment

• addition of cytidine to the culture medium during the activation rescues the proliferation defect of the CD8+ T cells

• however, no phenotypic differences are seen in the thymus and spleen, and no abnormalities are detected in blood, spleen cellularity and cell type composition

Allelic Composition	Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Commd10^{Tg(Vav1-icre)A2Kio}/0
Genetic Background	B6.Cg-Ctps1^{tm1c(KOMP)Wtsi} Commd10^{Tg(Vav1-icre)A2Kio}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Ctps1^{tm1c(KOMP)Wtsi} mutation (0 available); any Ctps1 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:348981 )

• mice do not survive after 6 weeks of age

prenatal lethality, incomplete penetrance ( J:348981 )

• fewer than the expected numbers of mice are obtained

endocrine/exocrine glands

small thymus ( J:348981 )

thymus hypoplasia ( J:348981 )

• cellularity of thymus is reduced

growth/size/body

decreased body size ( J:348981 )

hematopoietic system

decreased T cell proliferation ( J:348981 )

• double positive cells are reduced and single positive CD4 and CD8 cells are increased, suggesting reduced proliferation of double negative thymocytes leading to double positive stage

small thymus ( J:348981 )

thymus hypoplasia ( J:348981 )

• cellularity of thymus is reduced

anemia ( J:348981 )

• severe anemia

decreased bone marrow cell number ( J:348981 )

• bone marrow cellularity is reduced, with the percentage of Ter119+ bone marrow cells, corresponding to erythrocyte progenitors, is strongly decreased

• absolute numbers of erythroid and hematopoietic progenitors are reduced as bone marrow cellularity is reduced

• however, the percentage of LSK+ cells in bone marrow is normal

decreased B cell number ( J:348981 )

• absolute numbers of B lymphocytes are reduced in the spleen

decreased NK cell number ( J:348981 )

• absolute numbers of NK cells are reduced in the spleen

increased CD4-positive, alpha-beta T cell number ( J:348981 )

increased CD8-positive, alpha-beta T cell number ( J:348981 )

decreased T cell number ( J:348981 )

• absolute numbers of T lymphocytes are reduced in the spleen

decreased double-positive T cell number ( J:348981 )

decreased hematopoietic stem cell number ( J:348981 )

• absolute numbers of hematopoietic progenitors are reduced as bone marrow cellularity is reduced

decreased megakaryocyte-erythroid progenitor cell number ( J:348981 )

• the percentage of Ter119+ bone marrow cells, corresponding to erythrocyte progenitors, is strongly decreased

abnormal spleen morphology ( J:348981 )

• spleen cellularity is normal but absolute numbers of B and T lymphocytes and NK cells are reduced, while macrophages and granulocytes are not affected

immune system

decreased T cell proliferation ( J:348981 )

• double positive cells are reduced and single positive CD4 and CD8 cells are increased, suggesting reduced proliferation of double negative thymocytes leading to double positive stage

small thymus ( J:348981 )

thymus hypoplasia ( J:348981 )

• cellularity of thymus is reduced

decreased B cell number ( J:348981 )

• absolute numbers of B lymphocytes are reduced in the spleen

decreased NK cell number ( J:348981 )

• absolute numbers of NK cells are reduced in the spleen

increased CD4-positive, alpha-beta T cell number ( J:348981 )

increased CD8-positive, alpha-beta T cell number ( J:348981 )

decreased T cell number ( J:348981 )

• absolute numbers of T lymphocytes are reduced in the spleen

decreased double-positive T cell number ( J:348981 )

abnormal spleen morphology ( J:348981 )

• spleen cellularity is normal but absolute numbers of B and T lymphocytes and NK cells are reduced, while macrophages and granulocytes are not affected

cellular

decreased T cell proliferation ( J:348981 )

• double positive cells are reduced and single positive CD4 and CD8 cells are increased, suggesting reduced proliferation of double negative thymocytes leading to double positive stage

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:348981 )

• mice show a drastic weight loss upon tamoxifen treatment by day 6

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:348981 )

• tamoxifen-treated mice show numerous empty crypts and vacuoles

small thymus ( J:348981 )

• thymus is smaller in tamoxifen-treated mice

thymus hypoplasia ( J:348981 )

• thymus cellularity is reduced 10-fold in tamoxifen-treated mice

abnormal thymus physiology ( J:348981 )

• most cells in the thymus of tamoxifen-treated mice are CD4-/CD8- double negative, suggesting impaired proliferation capacity of early thymocytes

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:348981 )

• tamoxifen-treated mice exhibit aberrant gut structures, with lamina propria that is detaching from the epithelium and abnormal cell shedding at the top of the villi

abnormal small intestine crypts of Lieberkuhn morphology ( J:348981 )

• tamoxifen-treated mice show numerous empty crypts and vacuoles

abnormal small intestinal villus morphology ( J:348981 )

• abnormal cell shedding at the top of the villi in tamoxifen-treated mice

decreased small intestinal villus height ( J:348981 )

• length of villi is reduced in tamoxifen-treated mice

hematopoietic system

decreased T cell proliferation ( J:348981 )

• the expansion of splenic T cells in response to CD3 and CD28 stimulation is impaired in tamoxifen-treated mice

• proliferation of sorted splenic B cells upon stimulation with LPS plus IL-4 is reduced in tamoxifen-treated mice

small thymus ( J:348981 )

• thymus is smaller in tamoxifen-treated mice

thymus hypoplasia ( J:348981 )

• thymus cellularity is reduced 10-fold in tamoxifen-treated mice

abnormal thymus physiology ( J:348981 )

• most cells in the thymus of tamoxifen-treated mice are CD4-/CD8- double negative, suggesting impaired proliferation capacity of early thymocytes

decreased erythrocyte cell number ( J:348981 )

• red blood cell numbers are reduced in tamoxifen-treated mice

decreased hemoglobin content ( J:348981 )

• hemoglobin is reduced in tamoxifen-treated mice

increased CD8-positive, alpha-beta T cell number ( J:348981 )

• spleen shows a slight increase of CD8+ T cells in tamoxifen-treated mice

decreased lymphocyte cell number ( J:348981 )

• lymphocyte numbers are reduced in tamoxifen-treated mice

• however, no differences are seen in total number of whole blood cells and neutrophils

decreased germinal center B cell number ( J:348981 )

• CD19+CD95+GL-7+ germinal center B cells are almost absent in tamoxifen-treated mice (activated B cells)

• however, proportions of T and B cells in Peyers patches are normal

decreased T follicular helper cell number ( J:348981 )

• CXCR5+PD-1+ T follicular helper cells are reduced in germinal centers of tamoxifen-treated mice

• percentage of CXCR5+PD-1+ T follicular helper cells is reduced after immunization with NP-CGG

reticulocytopenia ( J:348981 )

• tamoxifen-treated mice show a drop in reticulocyte numbers

abnormal spleen morphology ( J:348981 )

• spleen shows a cellularity and composition similar to controls except for a slight increase of CD8+ T cells

decreased IgM level ( J:348981 )

• tamoxifen-treated mice immunized with NP-CGG show a reduction of NP-specific IgM

immune system

decreased T cell proliferation ( J:348981 )

• the expansion of splenic T cells in response to CD3 and CD28 stimulation is impaired in tamoxifen-treated mice

• proliferation of sorted splenic B cells upon stimulation with LPS plus IL-4 is reduced in tamoxifen-treated mice

small thymus ( J:348981 )

• thymus is smaller in tamoxifen-treated mice

thymus hypoplasia ( J:348981 )

• thymus cellularity is reduced 10-fold in tamoxifen-treated mice

abnormal thymus physiology ( J:348981 )

• most cells in the thymus of tamoxifen-treated mice are CD4-/CD8- double negative, suggesting impaired proliferation capacity of early thymocytes

increased CD8-positive, alpha-beta T cell number ( J:348981 )

• spleen shows a slight increase of CD8+ T cells in tamoxifen-treated mice

decreased lymphocyte cell number ( J:348981 )

• lymphocyte numbers are reduced in tamoxifen-treated mice

• however, no differences are seen in total number of whole blood cells and neutrophils

decreased germinal center B cell number ( J:348981 )

• CD19+CD95+GL-7+ germinal center B cells are almost absent in tamoxifen-treated mice (activated B cells)

• however, proportions of T and B cells in Peyers patches are normal

decreased T follicular helper cell number ( J:348981 )

• CXCR5+PD-1+ T follicular helper cells are reduced in germinal centers of tamoxifen-treated mice

• percentage of CXCR5+PD-1+ T follicular helper cells is reduced after immunization with NP-CGG

abnormal spleen morphology ( J:348981 )

• spleen shows a cellularity and composition similar to controls except for a slight increase of CD8+ T cells

decreased IgM level ( J:348981 )

• tamoxifen-treated mice immunized with NP-CGG show a reduction of NP-specific IgM

impaired humoral immune response ( J:348981 )

• capacity to mount humoral immune responses against the T-dependent antigen 4-hydroxy-3-nitrophenyl (NP) hapten conjugated to chicken gamma globulin (CGG) is reduced in tamoxifen-treated mice

• spleen histology after immunization with NP-CGG shows a reduction of proliferating B cells

cellular

decreased T cell proliferation ( J:348981 )

• the expansion of splenic T cells in response to CD3 and CD28 stimulation is impaired in tamoxifen-treated mice

• proliferation of sorted splenic B cells upon stimulation with LPS plus IL-4 is reduced in tamoxifen-treated mice

Allelic Composition	Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctps1^{tm1c(KOMP)Wtsi} mutation (0 available); any Ctps1 mutation (46 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:348981 )

• both CD4 and CD8 enriched splenic T cells show a reduction in proliferation upon CD3/CD28 stimulation

increased CD8-positive, naive alpha-beta T cell number ( J:348981 )

• after 3 days of activation, an increase of naive (CD44-CD62L+) T cells is seen

decreased effector memory T-helper cell number ( J:348981 )

• after 3 days of activation, a reduction of effector memory cells (CD44+CD62L-) is seen

hematopoietic system

decreased T cell proliferation ( J:348981 )

• both CD4 and CD8 enriched splenic T cells show a reduction in proliferation upon CD3/CD28 stimulation

increased CD8-positive, naive alpha-beta T cell number ( J:348981 )

• after 3 days of activation, an increase of naive (CD44-CD62L+) T cells is seen

decreased effector memory T-helper cell number ( J:348981 )

• after 3 days of activation, a reduction of effector memory cells (CD44+CD62L-) is seen

cellular

decreased T cell proliferation ( J:348981 )

• both CD4 and CD8 enriched splenic T cells show a reduction in proliferation upon CD3/CD28 stimulation

Allelic Composition	Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Ctps2^{tm1c(EUCOMM)Hmgu}/Ctps2^{tm1c(EUCOMM)Hmgu} Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctps1^{tm1c(KOMP)Wtsi} mutation (0 available); any Ctps1 mutation (46 available)
Ctps2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Ctps2 mutation (17 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:348981 )

• almost complete absence of activated CD4+ and CD8+ T lymphocyte proliferation

decreased T cell number ( J:348981 )

• T lymphocyte counts are diminished

• however, cellularity and cell population distribution of blood, thymus, and spleen are normal

hematopoietic system

decreased T cell proliferation ( J:348981 )

• almost complete absence of activated CD4+ and CD8+ T lymphocyte proliferation

decreased T cell number ( J:348981 )

• T lymphocyte counts are diminished

• however, cellularity and cell population distribution of blood, thymus, and spleen are normal

cellular

decreased T cell proliferation ( J:348981 )

• almost complete absence of activated CD4+ and CD8+ T lymphocyte proliferation

Allelic Composition	Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Ctps2^{tm1c(EUCOMM)Hmgu}/Ctps2⁺ Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S/Sv * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:348981 )

• T lymphocytes show reduced proliferation

hematopoietic system

decreased T cell proliferation ( J:348981 )

• T lymphocytes show reduced proliferation

cellular

decreased T cell proliferation ( J:348981 )

• T lymphocytes show reduced proliferation

Allelic Composition	Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd4-cre)1Cwi/0 Foxp3^sf/Y Rag1^tm1Mom/Rag1⁺
Genetic Background	mixed

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctps1^{tm1c(KOMP)Wtsi} mutation (0 available); any Ctps1 mutation (46 available)
Foxp3^sf mutation (5 available); any Foxp3 mutation (57 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (122 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:348981 )

• weight does not reach control levels at 40-50 days and 60-75 days

enlarged spleen ( J:348981 )

• by day 44, mice develop enlarged spleen

endocrine/exocrine glands

thymus hypoplasia ( J:348981 )

• by day 44, thymus has reduced cellularity

immune system

decreased T cell proliferation ( J:348981 )

• both CD8+ and CD4+ T cells show a reduced capacity to expand in response to CD3/CD28 stimulation

thymus hypoplasia ( J:348981 )

• by day 44, thymus has reduced cellularity

enlarged spleen ( J:348981 )

• by day 44, mice develop enlarged spleen

decreased regulatory T cell number ( J:348981 )

• mice exhibit a deficiency in T regulatory cells (CD4+, CD25+, FoxP3+)

decreased inflammatory response ( J:348981 )

• mice show prevention of the fatal systemic autoimmune and inflammatory disease that is seen in Foxp3^sf/Y mice, with mice surviving at least up to 80 days and no presentation of scaly tails and ears, and no inflammation and tissue disruption at day 44

• values of total T cells return to normal and the accumulation of effector memory CD4+ and CD8+ T cells in the spleen that is seen in single Foxp3/Y mice is reduced

hematopoietic system

decreased T cell proliferation ( J:348981 )

• both CD8+ and CD4+ T cells show a reduced capacity to expand in response to CD3/CD28 stimulation

thymus hypoplasia ( J:348981 )

• by day 44, thymus has reduced cellularity

enlarged spleen ( J:348981 )

• by day 44, mice develop enlarged spleen

decreased regulatory T cell number ( J:348981 )

• mice exhibit a deficiency in T regulatory cells (CD4+, CD25+, FoxP3+)

cellular

decreased T cell proliferation ( J:348981 )

• both CD8+ and CD4+ T cells show a reduced capacity to expand in response to CD3/CD28 stimulation

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