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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctps2tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:7657753
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ctps1tm1c(KOMP)Wtsi/Ctps1tm1c(KOMP)Wtsi
Ctps2tm1c(EUCOMM)Hmgu/Ctps2tm1c(EUCOMM)Hmgu
Tg(Cd4-cre)1Cwi/0 		involves: 129S/Sv * C57BL/6 * DBA/2 MGI:7659102
cn2
 		Ctps1tm1c(KOMP)Wtsi/Ctps1tm1c(KOMP)Wtsi
Ctps2tm1c(EUCOMM)Hmgu/Ctps2+
Tg(Cd4-cre)1Cwi/0 		involves: 129S/Sv * C57BL/6 * DBA/2 MGI:7659103


Genotype
MGI:7659102
cn1
Allelic
Composition		 Ctps1tm1c(KOMP)Wtsi/Ctps1tm1c(KOMP)Wtsi
Ctps2tm1c(EUCOMM)Hmgu/Ctps2tm1c(EUCOMM)Hmgu
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctps1tm1c(KOMP)Wtsi mutation (0 available); any Ctps1 mutation (46 available)
Ctps2tm1c(EUCOMM)Hmgu mutation (0 available); any Ctps2 mutation (17 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:348981 )
• almost complete absence of activated CD4+ and CD8+ T lymphocyte proliferation
decreased T cell number ( J:348981 )
• T lymphocyte counts are diminished
• however, cellularity and cell population distribution of blood, thymus, and spleen are normal

hematopoietic system
decreased T cell proliferation ( J:348981 )
• almost complete absence of activated CD4+ and CD8+ T lymphocyte proliferation
decreased T cell number ( J:348981 )
• T lymphocyte counts are diminished
• however, cellularity and cell population distribution of blood, thymus, and spleen are normal

cellular
decreased T cell proliferation ( J:348981 )
• almost complete absence of activated CD4+ and CD8+ T lymphocyte proliferation




Genotype
MGI:7659103
cn2
Allelic
Composition		 Ctps1tm1c(KOMP)Wtsi/Ctps1tm1c(KOMP)Wtsi
Ctps2tm1c(EUCOMM)Hmgu/Ctps2+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctps1tm1c(KOMP)Wtsi mutation (0 available); any Ctps1 mutation (46 available)
Ctps2tm1c(EUCOMM)Hmgu mutation (0 available); any Ctps2 mutation (17 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:348981 )
• T lymphocytes show reduced proliferation

hematopoietic system
decreased T cell proliferation ( J:348981 )
• T lymphocytes show reduced proliferation

cellular
decreased T cell proliferation ( J:348981 )
• T lymphocytes show reduced proliferation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory