Phenotypes associated with this allele

• Allele Symbol: Il11^tm1Moto
• Allele Name: targeted mutation 1, Toshio Matsumoto
• Allele ID: MGI:7659208
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il11^tm1Moto/Il11^tm1Moto	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:7659213

Genotype
MGI:7659213

hm1

• Allelic Composition: Il11^tm1Moto/Il11^tm1Moto
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased white adipose tissue amount ( J:345337 )

♀

increased bone marrow adipose tissue amount ( J:345337 )

♀ • bone marrow adiposity is increased in a time-dependent manner

abnormal fat cell differentiation ( J:345337 )

♀ • adipocyte differentiation of bone marrow stromal cells is enhanced

abnormal white fat cell morphology ( J:345337 )

♀ • adipose tissue weight is increased under both regular diet and high-fat diet, and total, visceral and subcutaneous adipose tissue area is larger

♀ • however, brown adipose tissue weight is normal

increased white fat cell number ( J:345337 )

♀ • relative number of adipocytes is increased

increased fat cell size ( J:345337 )

♀ • adipocyte diameter is increased

cellular

abnormal fat cell differentiation ( J:345337 )

♀ • adipocyte differentiation of bone marrow stromal cells is enhanced

impaired osteoblast differentiation ( J:345337 )

♀ • osteoblast differentiation of bone marrow stromal cells is reduced

growth/size/body

growth/size/body region phenotype ( J:345337 )

♀N • body weight gain and size are not different from wild-type mice

homeostasis/metabolism

increased circulating leptin level ( J:345337 )

♀ • mice show higher leptin level when fed a high-fat diet

♀ • however, leptin level is normal on a regular diet

impaired glucose tolerance ( J:345337 )

♀ • mice develop glucose intolerance, showing increased blood glucose in an oral glucose tolerance test when fed either a regular diet or high-fat diet

insulin resistance ( J:345337 )

♀ • mice develop insulin resistance, showing increased fasting level of serum insulin in an oral glucose tolerance test

♀ • homeostasis model assessment of insulin resistance (HOMA-IR) is increased

decreased adiponectin level ( J:345337 )

♀ • mice show lower adiponectin levels when fed a high-fat diet

♀ • however, adiponectin levels are normal on a regular diet

reproductive system

female infertility ( J:345337 )

♀

skeleton

increased bone marrow adipose tissue amount ( J:345337 )

♀ • bone marrow adiposity is increased in a time-dependent manner

impaired osteoblast differentiation ( J:345337 )

♀ • osteoblast differentiation of bone marrow stromal cells is reduced

abnormal vertebrae morphology ( J:345337 )

♀ • vertebral bone mass is reduced

decreased bone mineral density ( J:345337 )

♀ • total, cortical, and cancellous bone mineral density of the vertebra and femur are reduced after weaning

♀ • however, bone mineral density of calvaria, a non-weight bearing bone, is almost the same as in wild-type mice

decreased bone mineral density of vertebrae ( J:345337 )

♀

decreased bone mineral density of femur ( J:345337 )

♀

abnormal compact bone morphology ( J:345337 )

♀ • cortical bone mineral density of the vertebra and femur are reduced after weaning

abnormal trabecular bone morphology ( J:345337 )

♀ • cancellous bone mineral density of the vertebra and femur are reduced after weaning

decreased bone mass ( J:345337 )

♀

abnormal ossification involved in bone remodeling ( J:345337 )

♀ • bone formation response to mechanical reloading is blunted, with bone formation parameters after reloading not recovering fully and bone resorption parameters decreasing to baseline levels

decreased bone ossification ( J:345337 )

♀ • vertebra show reduced bone formation and unchanged bone resorption

♀ • serum bone formation markers are reduced while bone resorption marker is unchanged