Analysis Tools
adipose tissue
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• adipose tissue area is increased in mice fed either regular diet or high-fat diet but is larger in mice under high-fat diet than under regular diet
• treatment with WAY-262611, a beta-catenin agonist and Dkk1 inhibitor, reduces adipose tissue area
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homeostasis/metabolism
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• serum osteocalcin levels are reduced
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• serum IL-11 levels are reduced
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• mice develop glucose intolerance, showing increased blood glucose after glucose loading by oral glucose tolerance test under both regular diet and high-fat diet
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• mice develop insulin resistance, showing increased fasting level of serum insulin in an oral glucose tolerance test
• homeostasis model assessment of insulin resistance (HOMA-IR) is increased under regular diet and high-fat diet
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immune system
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• serum IL-11 levels are reduced
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skeleton
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• decrease in cortical and cancellous bone mineral density
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• while mechanical unloading reduces vertebral cancellous bone marrow density as in controls, mechanical reloading shows a lower increase in bone marrow density than seen in controls
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