Phenotypes associated with this allele

• Allele Symbol: Slc13a3^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:7660528
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Aspa^nur7/Aspa^nur7 Slc13a3^tm1c(KOMP)Wtsi/Slc13a3^tm1c(KOMP)Wtsi Tg(GFAP-cre/ERT2)505Fmv/0	mixed	MGI:7660713

Genotype
MGI:7660713

cn1

• Allelic Composition: Aspa^nur7/Aspa^nur7; Slc13a3^{tm1c(KOMP)Wtsi}/Slc13a3^{tm1c(KOMP)Wtsi}; Tg(GFAP-cre/ERT2)505Fmv/0
• Genetic Background: mixed

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:349783 )

• at 16 weeks of age, concentration of the aspartoacylase substrate N-acetyl-L-aspartate (NAA) in brain in tamoxifen-treated mice is 55% below that in tamoxifen-treated control homozygous Aspa^nur7 mice, indicating partial reversal of increased brain NAA levels seen in Canavan disease model Aspa^nur7 mice

brain vacuoles ( J:349783 )

• the extent of cerebellar vacuolation in tamoxifen-treated mice is not different from that seen in homozygous Aspa^nur7 mice

behavior/neurological

enhanced coordination ( J:349783 )

• accelerating rotarod retention time is increased by 1 week after completion of tamoxifen administration and remains elevated through 7 additional weeks compared to homozygous Aspa^nur7 mice, indicating improved motor function