Analysis Tools
digestive/alimentary system
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• expression analysis indicates enhanced differentiation and increased numbers of goblet cells
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• increased proliferation of intestinal stem cells in the colon and in culture
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• intestinal epithelial barrier integrity degradation in response to DSS is reduced at 2.5 days post treatment as determined by increased leakage of FITC-dextran into the blood stream in wild-type mice but not mutants
• increased expression of tight junction proteins
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• reduced endocytosis of Occludin in TNF-treated cells in culture
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• show milder symptoms (decreased weight loss, decreased Disease Activity Index, longer colons, reduced histological colon damage) following dextran sodium sulfate (DSS)-induced colitis
• no differences in body weight or colon length are seen in the absence of DSS treatment
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immune system
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• show milder symptoms (decreased weight loss, decreased Disease Activity Index, longer colons, reduced histological colon damage) following dextran sodium sulfate (DSS)-induced colitis
• no differences in body weight or colon length are seen in the absence of DSS treatment
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• decrease in DSS-stimulated expression of Il1b and Il6
• cultured bone marrow derived macrophages show reduced Il1b and Il6 expression after LPS and Ifng treatment
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homeostasis/metabolism
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• intestinal epithelial barrier integrity degradation in response to DSS is reduced at 2.5 days post treatment as determined by increased leakage of FITC-dextran into the blood stream in wild-type mice but not mutants
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endocrine/exocrine glands
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• expression analysis indicates enhanced differentiation and increased numbers of goblet cells
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cellular
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• expression analysis indicates enhanced differentiation and increased numbers of goblet cells
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hematopoietic system
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• decrease in DSS-stimulated expression of Il1b and Il6
• cultured bone marrow derived macrophages show reduced Il1b and Il6 expression after LPS and Ifng treatment
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