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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim71tm1695Arte
targeted mutation 1695, TaconicArtemis
MGI:7661049
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Trim71tm1695Arte/Trim71tm1695Arte
Tg(tetO-cre)1Jaw/0
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ 		B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Trim71tm1695Arte Tg(tetO-cre)1Jaw MGI:7778319
cn2
 		Trim71tm1695Arte/Trim71tm1695Arte
Tg(Nes-cre)1Kln/0 		involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL MGI:7767876


Genotype
MGI:7778319
cn1
Allelic
Composition		 Trim71tm1695Arte/Trim71tm1695Arte
Tg(tetO-cre)1Jaw/0
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Trim71tm1695Arte Tg(tetO-cre)1Jaw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(tetO-cre)1Jaw mutation (6 available)
Trim71tm1695Arte mutation (0 available); any Trim71 mutation (170 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:335575 )
• doxycycline treatment at E5.5 results in completely penetrant neural tube defects at E12.5
• however, doxycycline treatment at P0.5 results in normal brain development

nervous system
abnormal neural tube morphology ( J:335575 )
• doxycycline treatment at E5.5 results in completely penetrant neural tube defects at E12.5
• however, doxycycline treatment at P0.5 results in normal brain development




Genotype
MGI:7767876
cn2
Allelic
Composition		 Trim71tm1695Arte/Trim71tm1695Arte
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Trim71tm1695Arte mutation (0 available); any Trim71 mutation (170 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron proliferation ( J:335575 )
• subventricular zone neural proliferation is reduced in hydrocephalic mice at P0
cerebral aqueductal stenosis ( J:335575 )
• P0 hydrocephalic mice exhibit patency of the midbrain cerebral aqueduct (aqueductal stenosis)
• however, ependymal and choroid plexus cells appear morphologically normal in P0 hydrocephalic mice
enlarged brain ventricles ( J:335575 )
• approximately 16% of mice exhibit ventriculomegaly
thin cerebral cortex ( J:335575 )
• hydrocephalic mice exhibit a thinned cerebral cortex at P0 with reduced thickness of the superficial and deep cortical layers
decreased neuron number ( J:335575 )
• marker analysis shows reduced numbers of neurons in cortical layers in hydrocephalic mice at P0

cellular
abnormal neuron proliferation ( J:335575 )
• subventricular zone neural proliferation is reduced in hydrocephalic mice at P0




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory