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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cep135em1Mama
endonuclease-mediated mutation 1, Marcos Malumbres
MGI:7661140
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cep135em1Mama/Cep135em1Mama involves: C57BL/6 * C57BL/6J * CBA MGI:7662411
ht2
 		Cep135em1Mama/Cep135em2Mama involves: C57BL/6 * C57BL/6J * CBA MGI:7662413


Genotype
MGI:7662411
hm1
Allelic
Composition		 Cep135em1Mama/Cep135em1Mama
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep135em1Mama mutation (0 available); any Cep135 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
microcephaly ( J:310617 )
• newborns exhibit mild primary microcephaly with an approximate 24.5% reduction in cortical area

nervous system
decreased neocortex size ( J:310617 )
• approximate 24.5% reduction in cortical area in newborns

cellular
cellular phenotype ( J:310617 )
N
• mouse embryonic fibroblasts (MEFs) do not present significant centrosome duplication defects




Genotype
MGI:7662413
ht2
Allelic
Composition		 Cep135em1Mama/Cep135em2Mama
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep135em1Mama mutation (0 available); any Cep135 mutation (72 available)
Cep135em2Mama mutation (0 available); any Cep135 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
microcephaly ( J:310617 )
• newborns exhibit mild primary microcephaly with an approximate 24.7% reduction in cortical area

nervous system
decreased neocortex size ( J:310617 )
• approximate 24.7% reduction in cortical area




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory