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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aspmem1Mama
endonuclease-mediated mutation 1, Marcos Malumbres
MGI:7661142
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aspmem1Mama/Aspmem1Mama involves: C57BL/6 * C57BL/6J * CBA MGI:7662410


Genotype
MGI:7662410
hm1
Allelic
Composition		 Aspmem1Mama/Aspmem1Mama
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aspmem1Mama mutation (0 available); any Aspm mutation (138 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased brain weight ( J:310617 )
• decrease in brain weight and skull volume at P30
abnormal neocortex morphology ( J:310617 )
• cortical thickness is reduced in E14.5 and P30 neocortices

reproductive system
abnormal male germ cell physiology ( J:310617 )
• reduction in maturation of germ cells in the testis

cellular
cellular phenotype ( J:310617 )
N
• mouse embryonic fibroblasts (MEFs) do not present significant centrosome duplication defects
abnormal male germ cell physiology ( J:310617 )
• reduction in maturation of germ cells in the testis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory