Phenotypes associated with this allele

• Allele Symbol: Cdk5rap2^em1Mama
• Allele Name: endonuclease-mediated mutation 1, Marcos Malumbres
• Allele ID: MGI:7661143
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk5rap2^em1Mama/Cdk5rap2^em1Mama	involves: C57BL/6 * C57BL/6J * CBA	MGI:7662409
cx2	Cdk5rap2^em1Mama/Cdk5rap2^em1Mama Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA	MGI:7662417

Genotype
MGI:7662409

hm1

• Allelic Composition: Cdk5rap2^em1Mama/Cdk5rap2^em1Mama
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain weight ( J:310617 )

• decrease in brain weight and skull volume at P30

abnormal neocortex morphology ( J:310617 )

• cortical thickness is reduced in E14.5 and P30 neocortices

reproductive system

abnormal male germ cell physiology ( J:310617 )

♂ • reduction in maturation of germ cells in the testis

vision/eye

abnormal retina development ( J:310617 )

• defect in retinal development

microphthalmia ( J:310617 )

cellular

cellular phenotype ( J:310617 )

N • mouse embryonic fibroblasts (MEFs) do not present significant centrosome duplication defects

abnormal male germ cell physiology ( J:310617 )

♂ • reduction in maturation of germ cells in the testis

Genotype
MGI:7662417

cx2

• Allelic Composition: Cdk5rap2^em1Mama/Cdk5rap2^em1Mama; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:310617 )

• lethality around E11.5