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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pias3em1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:7662566
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pias3em1Cya/Pias3em1Cya involves: C57BL/6N MGI:7662567


Genotype
MGI:7662567
hm1
Allelic
Composition		 Pias3em1Cya/Pias3em1Cya
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pias3em1Cya mutation (0 available); any Pias3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to induced aneurysm formation ( J:345238 )
• expansion of abdominal aortic aneurysms induced by transient luminal infusion of porcine pancreatic elastase (PPE) is reduced by approximately 50%
• destruction of medial elastin and smooth muscle cell loss following PPE infusion is reduced
• reduced accumulation of leukocytes following PPE infusion
• mural angiogenesis is suppressed by 40% following PPE infusion




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory