Phenotypes associated with this allele

• Allele Symbol: Pias3^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7662566
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pias3^em1Cya/Pias3^em1Cya	involves: C57BL/6N	MGI:7662567

Genotype
MGI:7662567

hm1

• Allelic Composition: Pias3^em1Cya/Pias3^em1Cya
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to induced aneurysm formation ( J:345238 )

• expansion of abdominal aortic aneurysms induced by transient luminal infusion of porcine pancreatic elastase (PPE) is reduced by approximately 50%

• destruction of medial elastin and smooth muscle cell loss following PPE infusion is reduced

• reduced accumulation of leukocytes following PPE infusion

• mural angiogenesis is suppressed by 40% following PPE infusion