Phenotypes associated with this allele

• Allele Symbol: Naalad2^em1Jzhan
• Allele Name: endonuclease-mediated mutation 1, Jing Zhang
• Allele ID: MGI:7662575
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Naalad2^em1Jzhan/Naalad2^em1Jzhan	involves: C57BL/6	MGI:7662576
cx2	Folh1^em2Smoc/Folh1^em2Smoc Naalad2^em1Jzhan/Naalad2^em1Jzhan	involves: C57BL/6 * C57BL/6J	MGI:7662577

Genotype
MGI:7662576

hm1

• Allelic Composition: Naalad2^em1Jzhan/Naalad2^em1Jzhan
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:344894 )

N • glutamate elevation, neuronal damage and apoptosis, and impairment of spatial learning in response to traumatic brain injury are similar to wild-type controls

Genotype
MGI:7662577

cx2

• Allelic Composition: Folh1^em2Smoc/Folh1^em2Smoc; Naalad2^em1Jzhan/Naalad2^em1Jzhan
• Genetic Background: involves: C57BL/6 * C57BL/6J

homeostasis/metabolism

decreased glutamic acid level ( J:344894 )

• rise in levels of glutamate following traumatic brain injury is reduced compared to similarly treated wild-type controls

decreased susceptibility to injury ( J:344894 )

• rise in levels of glutamate following traumatic brain injury (TBI) is reduced compared to similarly treated wild-type controls

• decrease in neuronal damage and apoptosis following TBI

• recovery of neurons following TBI is enhanced compared to wild-type controls

• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls

behavior/neurological

enhanced spatial learning ( J:344894 )

• impairment of performance in a Morris water maze is reduced following TBI compared to similarly treated wild-type controls