Phenotypes associated with this allele

• Allele Symbol: Zfp280c^em1Xss
• Allele Name: endonuclease-mediated mutation 1, Xing-sheng Shu
• Allele ID: MGI:7662826
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp280c^em1Xss/Zfp280c^em1Xss	C57BL/6J-Zfp280c^em1Xss	MGI:7662829
cx2	Apc^Min/Apc^+ Zfp280c^em1Xss/Zfp280c^em1Xss	C57BL/6J-Apc^Min Zfp280c^em1Xss	MGI:7662831
cx3	Apc^Min/Apc^+ Zfp280c^em1Xss/Y	C57BL/6J-Apc^Min Zfp280c^em1Xss	MGI:7662832
cx4	Apc^Min/Apc^+ Zfp280c^em1Xss/Zfp280c^+	C57BL/6J-Apc^Min Zfp280c^em1Xss	MGI:7662833

Genotype
MGI:7662829

hm1

• Allelic Composition: Zfp280c^em1Xss/Zfp280c^em1Xss
• Genetic Background: C57BL/6J-Zfp280c^em1Xss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:331404 )

♀ • mice treated with azoxymethane/dextran sulfate sodium (AOM/DSS) to induce colitis-associated cancer show greatly alleviated tumor burden in the colon and inhibited formation of large tumors compared to AOM/DSS-treated controls

♀ • AOM/DSS-treated mice show a decrease in adenomas of high-grade dysplasia and a reduction of Ki-67 positive cells in the colon epithelium

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:331404 )

♀ • mice treated with azoxymethane/dextran sulfate sodium (AOM/DSS) to induce colitis-associated cancer show greatly alleviated tumor burden in the colon and inhibited formation of large tumors compared to AOM/DSS-treated controls

♀ • AOM/DSS-treated mice show a decrease in adenomas of high-grade dysplasia and a reduction of Ki-67 positive cells in the colon epithelium

Genotype
MGI:7662831

cx2

• Allelic Composition: Apc^Min/Apc⁺; Zfp280c^em1Xss/Zfp280c^em1Xss
• Genetic Background: C57BL/6J-Apc^Min Zfp280c^em1Xss

mortality/aging

increased tumor-free survival time ( J:331404 )

♀ • mice show a prolonged lifespan, with a median survival time of 42.3 weeks compared to 24.6 weeks in single Apc^min heterozygotes

neoplasm

decreased alimentary system tumor incidence ( J:331404 )

♀ • mice show a consistent decrease in the tumor burden across the intestinal tract compared with single Apc^min mice

♀ • mice develop fewer polyps in the small intestine and the colon than single Apc^min mice at 20-24 weeks of age

♀ • the intestinal epithelium is largely normal with fewer Ki-67-positive cells in contrast to frequent carcinoma-like high-grade adenomas in the small intestine and colon in single Apc^min heterozygotes

digestive/alimentary system

decreased alimentary system tumor incidence ( J:331404 )

♀ • mice show a consistent decrease in the tumor burden across the intestinal tract compared with single Apc^min mice

♀ • mice develop fewer polyps in the small intestine and the colon than single Apc^min mice at 20-24 weeks of age

♀ • the intestinal epithelium is largely normal with fewer Ki-67-positive cells in contrast to frequent carcinoma-like high-grade adenomas in the small intestine and colon in single Apc^min heterozygotes

Genotype
MGI:7662832

cx3

• Allelic Composition: Apc^Min/Apc⁺; Zfp280c^em1Xss/Y
• Genetic Background: C57BL/6J-Apc^Min Zfp280c^em1Xss

mortality/aging

increased tumor-free survival time ( J:331404 )

♂ • mice show a medial survival time of 43.6 weeks which is longer than in single Apc^min heterozygotes with a median survival time of around 42 weeks

Genotype
MGI:7662833

cx4

• Allelic Composition: Apc^Min/Apc⁺; Zfp280c^em1Xss/Zfp280c⁺
• Genetic Background: C57BL/6J-Apc^Min Zfp280c^em1Xss

mortality/aging

increased tumor-free survival time ( J:331404 )

♀ • mice show a prolonged lifespan compared to single Apc^min heterozygotes