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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Leprottm1.2Damj
targeted mutation 1.2, Julie Dam
MGI:7662966
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Leprottm1.2Damj/Leprottm1.2Damj involves: 129S2/SvPas * C57BL/6N * FVB/N MGI:7662967


Genotype
MGI:7662967
hm1
Allelic
Composition
Leprottm1.2Damj/Leprottm1.2Damj
Genetic
Background
involves: 129S2/SvPas * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprottm1.2Damj mutation (0 available); any Leprot mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• on a high fat diet fat partitioning is altered with increased subcutaneous fat, gonadal depot and decreased liver fat
• however, body weight, lean mass and overall fat mass are similar to controls
• on a high fat diet

behavior/neurological
• food intake is reduced and treatment with leptin further reduces food intake compared to wild-type controls
• food intake is reduced on normal chow and high fat diets

homeostasis/metabolism
N
• levels of fasted metabolic hormones (leptin, insulin, C-peptide, glucagon, ghrelin, GLP1, amylin) are similar to controls
• on a high fat diet, energy expenditure, locomotor activity, and respiratory exchange ratio are similar to controls on both a normal chow and high fat diet
• glucose tolerance is preserved in mice after 4 weeks on a high fat diet unlike in diet matched wild-type controls
• on a normal chow diet glucose tolerance is similar to controls
• after 10 weeks on a high fat diet glucose intolerance is mild compared to diet matched wild-type controls
• in mice on a high fat diet compared to diet matched wild-type controls
• in mice on a high fat diet compared to a diet matched wild-type controls
• decreased expression of inflammatory cytokines in mice on a high fat diet

liver/biliary system

immune system
• decreased expression of inflammatory cytokines in mice on a high fat diet
• decrease in expression of inflammatory cytokines and markers of infiltrating macrophages in the liver and adipose tissue in mice on a high fat diet

integument





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory