Phenotypes associated with this allele

• Allele Symbol: Cdiptos^em1Sunb
• Allele Name: endonuclease-mediated mutation 1, Beicheng Sun
• Allele ID: MGI:7663892
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdiptos^em1Sunb/Cdiptos^em1Sunb	C57BL/6J-Cdiptos^em1Sunb	MGI:7663900

Genotype
MGI:7663900

hm1

• Allelic Composition: Cdiptos^em1Sunb/Cdiptos^em1Sunb
• Genetic Background: C57BL/6J-Cdiptos^em1Sunb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:321215 )

• mice treated with N-nitrosodiethylamine (DEN) and CCl4 to induce hepatocellular carcinoma show inhibition of hepatocellular carcinoma development, with decreased number of tumors, smaller tumor diameter and ratio of liver to body weight, lower levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), less bridging fibrosis and collagen deposition, reduced markers of liver inflammation, reduced proliferation capacity and increased apoptosis in the liver, and reduced microvessel density compared to controls

• mice treated with DEN to induce hepatocellular carcinoma form smaller and fewer tumors than treated wild-type mice, show reduced liver injury with lower levels of serum AST and ALT, reduced proliferation capacity and increased apoptosis in the liver, and reduced microvessel density

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:321215 )

• mice treated with N-nitrosodiethylamine (DEN) and CCl4 to induce hepatocellular carcinoma show inhibition of hepatocellular carcinoma development, with decreased number of tumors, smaller tumor diameter and ratio of liver to body weight, lower levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), less bridging fibrosis and collagen deposition, reduced markers of liver inflammation, reduced proliferation capacity and increased apoptosis in the liver, and reduced microvessel density compared to controls

• mice treated with DEN to induce hepatocellular carcinoma form smaller and fewer tumors than treated wild-type mice, show reduced liver injury with lower levels of serum AST and ALT, reduced proliferation capacity and increased apoptosis in the liver, and reduced microvessel density