Phenotypes associated with this allele

• Allele Symbol: Meis1^em1Rihw
• Allele Name: endonuclease-mediated mutation 1, Rhiannan H Williams
• Allele ID: MGI:7664086
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Meis1^em1Rihw/Meis1^em1Rihw	C57BL/6-Meis1^em1Rihw	MGI:7664129

Genotype
MGI:7664129

hm1

• Allelic Composition: Meis1^em1Rihw/Meis1^em1Rihw
• Genetic Background: C57BL/6-Meis1^em1Rihw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:350503 )

♀N • normal running wheel activity during dark phase in aged (10-11 months old) mice and during light period in all mice

♀N • normal locomotor activity in cage

♀N • normal locomotor activity during open field test

♀N • normal behavior in rotarod and hot plate tests

♀N • normal percent wake time in light and dark periods and normal wake activity

♀N • normal percent wake time during dusk

decreased locomotor activity ( J:350503 )

♀ • reduced running wheel activity during dark phase in young (2-3 months old) mice

♀ • normal running wheel activity during dark phase in aged (10-11 months old) mice and during light period in all mice

♀ • normal locomotor activity in cage

♀ • normal locomotor activity during open field test

abnormal circadian sleep/wake cycle ( J:350503 )

♀ • fewer sleep-wake transitions during dark period in aged (12-14 months old) mice

♀ • normal number of sleep-wake transitions during dark period in young (4-6 months old) mice

♀ • normal number of sleep-wake transitions during light period in all mice

abnormal sleep duration ( J:350503 )

♀ • longer sleep bout length in light period in aged (12-14 months old) mice

♀ • normal sleep bout length in light period in young (4-6 months old) mice

♀ • normal sleep bout length before dawn transition in all mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:350503 )

♀N • normal plasma concentrations of minerals and iron and normal alkaline phosphatase (ALP) activity

respiratory system

respiratory system phenotype ( J:350503 )

♀N • normal respiratory exchange ratio

♀N • normal breathing during sleep, including dusk and dawn

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
restless legs syndrome		DOID:0050425	OMIM:PS102300	J:350503