Phenotypes associated with this allele

• Allele Symbol: Dag1^tm1.1Sabl
• Allele Name: targeted mutation 1.1, Sandra Blaess
• Allele ID: MGI:7664416
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dag1^tm1.1Sabl/Dag1^tm1.1Sabl	involves: C57BL/6 * CD-1	MGI:7664431

Genotype
MGI:7664431

hm1

• Allelic Composition: Dag1^tm1.1Sabl/Dag1^tm1.1Sabl
• Genetic Background: involves: C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle fiber morphology ( J:350439 )

♂ • more quadriceps femoris muscles with centralized nuclei at ages 6 months and 1 year

♂ • normal number of quadriceps femoris muscles with centralized nuclei at ages 1 week and 2 months

abnormal muscle physiology ( J:350439 )

• lower average and maximum running speeds during dark phase in volunteer wheel running test with normal, modified (some rungs removed) or extensively modified (many rungs removed) wheel at age 1 year

• normal total time spent and length and number of sessions on normal or modified running wheel in dark phase at age 1 year

embryo

decreased embryo size ( J:350439 )

• for E9.5 and E10.5 embryos

abnormal Reichert's membrane morphology ( J:350439 )

• irregularly structured laminin in E8.5 embryos

mortality/aging

prenatal lethality, incomplete penetrance ( J:350439 )

• mice born at percentage significantly below expected Mendelian ratio

• normal Mendelian ratios at embryo stages E8.5, E9.5 and E10.5

growth/size/body

decreased embryo size ( J:350439 )

• for E9.5 and E10.5 embryos

decreased body weight ( J:350439 )

• at ages 2 and 6 months

nervous system

nervous system phenotype ( J:350439 )

N • no gross anatomical brain phenotypes

dilated lateral ventricle ( J:350439 )

• at age 1 week

• normal at age 6 months

behavior/neurological

behavior/neurological phenotype ( J:350439 )

N • no gross behavioral phenotype in home cage up to age 1 year

abnormal physical strength ( J:350439 )

• lower average and maximum running speeds during dark phase in volunteer wheel running test with normal, modified (some rungs removed) or extensively modified (many rungs removed) wheel at age 1 year

• normal total time spent and length and number of sessions on normal or modified running wheel in dark phase at age 1 year

reproductive system

reproductive system phenotype ( J:350439 )

N • fertile

vision/eye

vision/eye phenotype ( J:350439 )

N • no gross anatomical eye phenotypes