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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccdc28aem1Lwa
endonuclease-mediated mutation 1, Lei Wang
MGI:7664574
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccdc28aem1Lwa/Ccdc28aem1Lwa involves: C57BL/6N * DBA/2 MGI:7664627


Genotype
MGI:7664627
hm1
Allelic
Composition		 Ccdc28aem1Lwa/Ccdc28aem1Lwa
Genetic
Background		 involves: C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc28aem1Lwa mutation (0 available); any Ccdc28a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm head morphology ( J:350809 )
• sperm show head defects, including bent heads, microcephaly, and irregular shapes
• however, sperm flagellum shows normal morphology, with unaffected axoneme, outer dense fibers, and fibrous sheath
abnormal acroplaxome morphology ( J:350809 )
• spermatids show a relative loosened acroplaxome structure at the elongation/maturation acrosome phase of acrosome formation
abnormal acrosome morphology ( J:350809 )
• sperm show abnormal acrosome structures such as detachment of the acrosome from the nucleus, irregular-shaped acrosomes, and fragmented acrosomes
asthenozoospermia ( J:350809 )
• males exhibit a decrease in the percentage of motile sperm
• average path velocity, straight line velocity, and curvilinear velocity of sperm are decreased
male infertility ( J:350809 )
• males are infertile
• in vitro fertilization using excess sperm from the cauda epididymis shows decreased formation of the number of two-cell embryos
• the fertilization failure of males is rescued by intracytoplasmic sperm injection

cellular
abnormal sperm head morphology ( J:350809 )
• sperm show head defects, including bent heads, microcephaly, and irregular shapes
• however, sperm flagellum shows normal morphology, with unaffected axoneme, outer dense fibers, and fibrous sheath
abnormal acroplaxome morphology ( J:350809 )
• spermatids show a relative loosened acroplaxome structure at the elongation/maturation acrosome phase of acrosome formation
abnormal acrosome morphology ( J:350809 )
• sperm show abnormal acrosome structures such as detachment of the acrosome from the nucleus, irregular-shaped acrosomes, and fragmented acrosomes
asthenozoospermia ( J:350809 )
• males exhibit a decrease in the percentage of motile sperm
• average path velocity, straight line velocity, and curvilinear velocity of sperm are decreased




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory