Phenotypes associated with this allele

• Allele Symbol: Tspyl5^em1Yuya
• Allele Name: endonuclease-mediated mutation 1, Yuan Yang
• Allele ID: MGI:7665244
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tspyl5^em1Yuya/Tspyl5^em1Yuya	C57BL/6-Tspyl5^em1Yuya	MGI:7665246

Genotype
MGI:7665246

hm1

• Allelic Composition: Tspyl5^em1Yuya/Tspyl5^em1Yuya
• Genetic Background: C57BL/6-Tspyl5^em1Yuya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:350814 )

♂ • sperm counts are reduced in 18-month-old mice but not in 3-month-old mice

abnormal spermatogonia morphology ( J:350814 )

♂ • average spermatogonia number per seminiferous tubule is reduced at 18, but not 3, months of age

abnormal spermatogonia proliferation ( J:350814 )

♂ • the cluster size of spermatogonia derived from 18-month-old males grown in vitro is smaller

♂ • 2-D cell cycle analysis shows a decreased proliferation rate of spermatogonia from 18-month-old mice

♂ • cell cycle analysis on spermatogonia cells shows decreased proportion of S phase cells

abnormal male germ cell physiology ( J:350814 )

♂ • 18-month-old males show a decrease in the ratio of the G2 phase germ calls in testis, indicating reduced germ cell proliferation

abnormal testis morphology ( J:350814 )

♂ • testis volumes are reduced in 18-month-old mice

abnormal seminiferous tubule morphology ( J:350814 )

♂ • lumen diameter of some seminiferous tubules is enlarged by about 50%

♂ • the proportion of abnormal seminiferous tubules per testis is increased in 18-month-old mice

decreased testis weight ( J:350814 )

♂ • testis/body weight ratio is reduced in 18-month-old males

reduced male fertility ( J:350814 )

♂ • litter sizes of 18-month-old, but not 3-month-old, males mated with wild-type females are reduced, indicating reduced fertility with age

♂ • however, motility of sperm is normal in 18-month-old males

endocrine/exocrine glands

abnormal testis morphology ( J:350814 )

♂ • testis volumes are reduced in 18-month-old mice

abnormal seminiferous tubule morphology ( J:350814 )

♂ • lumen diameter of some seminiferous tubules is enlarged by about 50%

♂ • the proportion of abnormal seminiferous tubules per testis is increased in 18-month-old mice

decreased testis weight ( J:350814 )

♂ • testis/body weight ratio is reduced in 18-month-old males

cellular

oligozoospermia ( J:350814 )

♂ • sperm counts are reduced in 18-month-old mice but not in 3-month-old mice

abnormal spermatogonia morphology ( J:350814 )

♂ • average spermatogonia number per seminiferous tubule is reduced at 18, but not 3, months of age

abnormal spermatogonia proliferation ( J:350814 )

♂ • the cluster size of spermatogonia derived from 18-month-old males grown in vitro is smaller

♂ • 2-D cell cycle analysis shows a decreased proliferation rate of spermatogonia from 18-month-old mice

♂ • cell cycle analysis on spermatogonia cells shows decreased proportion of S phase cells

abnormal male germ cell physiology ( J:350814 )

♂ • 18-month-old males show a decrease in the ratio of the G2 phase germ calls in testis, indicating reduced germ cell proliferation