Phenotypes associated with this allele

• Allele Symbol: Cab39l^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:7665327
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cab39l^tm1d(EUCOMM)Wtsi/Cab39l^tm1d(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6NCr * CBA	MGI:7666122

Genotype
MGI:7666122

hm1

• Allelic Composition: Cab39l^{tm1d(EUCOMM)Wtsi}/Cab39l^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6NCr * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:350956 )

• bladder urothelium exhibits hyperplasia with distinct expansion of the basal undifferentiated layer

• about 70% of urothelial cells are basal cells compared to intermediate cells being the most dominant cell population in wild-type urothelium

neoplasm

increased incidence of tumors by chemical induction ( J:350956 )

• mice show increased susceptibility to N-butyl-N-(4-hydrdoxybutyl)nitrosamine (BBN)-induced bladder cancer, developing higher numbers of tumors than in wild-type mice

• mice sensitized with BBN develop intraurothelial precursor lesions that lead to carcinoma in situ characterized by the proliferation of undifferentiated KRT5/6-positive cells, consistent with the basal variant of carcinoma in situ

• tumors are high-grade invasive urothelial carcinomas that are poorly differentiated, with focal squamous features recapitulating basal urothelial carcinomas of the bladder

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:350956 )

• mice show increased susceptibility to N-butyl-N-(4-hydrdoxybutyl)nitrosamine (BBN)-induced bladder cancer, developing higher numbers of tumors than in wild-type mice

• mice sensitized with BBN develop intraurothelial precursor lesions that lead to carcinoma in situ characterized by the proliferation of undifferentiated KRT5/6-positive cells, consistent with the basal variant of carcinoma in situ

• tumors are high-grade invasive urothelial carcinomas that are poorly differentiated, with focal squamous features recapitulating basal urothelial carcinomas of the bladder