Phenotypes associated with this allele

• Allele Symbol: Lpar6^tm1.1Bcz
• Allele Name: targeted mutation 1.1, Bogdan Czerniak
• Allele ID: MGI:7665329
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lpar6^tm1.1Bcz/Lpar6^tm1.1Bcz	involves: 129 * BALB/cJ * C57BL/6J * C57BL/6NCr	MGI:7666120

Genotype
MGI:7666120

hm1

• Allelic Composition: Lpar6^tm1.1Bcz/Lpar6^tm1.1Bcz
• Genetic Background: involves: 129 * BALB/cJ * C57BL/6J * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:350956 )

• bladder urothelium exhibits hyperplasia, with cells undergoing a gradual transition from basal through intermediate to luminal urothelial layers

• more than 60% of urothelial cells are luminal cells compared to intermediate cells being the most dominant cell population in wild-type urothelium

neoplasm

increased incidence of tumors by chemical induction ( J:350956 )

• mice show increased susceptibility to N-butyl-N-(4-hydrdoxybutyl)nitrosamine (BBN)-induced bladder cancer, developing higher numbers of tumors than in wild-type mice

• mice sensitized with BBN develop intraurothelial precursor lesions that lead to carcinoma in situ that exhibits retention of KRT5/6 basal cells at the base of the urothelium and is consistent with luminal subtype of carcinoma in situ

• tumors are low-grade superficial noninvasive papillary and high-grade invasive urothelial carcinomas; all superficial papillary tumors are of the luminal subtype and invasive carcinomas are consistent with the luminal phenotype

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:350956 )

• mice show increased susceptibility to N-butyl-N-(4-hydrdoxybutyl)nitrosamine (BBN)-induced bladder cancer, developing higher numbers of tumors than in wild-type mice

• mice sensitized with BBN develop intraurothelial precursor lesions that lead to carcinoma in situ that exhibits retention of KRT5/6 basal cells at the base of the urothelium and is consistent with luminal subtype of carcinoma in situ

• tumors are low-grade superficial noninvasive papillary and high-grade invasive urothelial carcinomas; all superficial papillary tumors are of the luminal subtype and invasive carcinomas are consistent with the luminal phenotype