Phenotypes associated with this allele

• Allele Symbol: Garin2^em1Osb
• Allele Name: endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:7666151
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Garin2^em1Osb/Garin2^em1Osb	involves: C57BL/6 * DBA/2	MGI:7666358

Genotype
MGI:7666358

hm1

• Allelic Composition: Garin2^em1Osb/Garin2^em1Osb
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm head morphology ( J:350937 )

♂ • 88.4% of sperm heads exhibit bluntness in the hook regions

♂ • however, the acrosome appears normal

asthenozoospermia ( J:350937 )

♂ • the percentage of motile spermatozoa is decreased

♂ • curvilinear velocity and average path velocity of spermatozoa is lower after 120 minutes of incubation in a capacitation medium

impaired sperm penetration of zona pellucida ( J:350937 )

♂ • although males are fertile, zona pellucida penetration ability of sperm is reduced in in vitro fertilization

cellular

abnormal sperm head morphology ( J:350937 )

♂ • 88.4% of sperm heads exhibit bluntness in the hook regions

♂ • however, the acrosome appears normal

asthenozoospermia ( J:350937 )

♂ • the percentage of motile spermatozoa is decreased

♂ • curvilinear velocity and average path velocity of spermatozoa is lower after 120 minutes of incubation in a capacitation medium