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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Garin5aem1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:7666154
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Garin5aem1Osb/Garin5aem1Osb involves: C57BL/6 * DBA/2 MGI:7666407


Genotype
MGI:7666407
hm1
Allelic
Composition		 Garin5aem1Osb/Garin5aem1Osb
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Garin5aem1Osb mutation (0 available); any Garin5a mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm head morphology ( J:350937 )
• 47% of sperm heads exhibit bluntness in the hook regions
• however, the acrosome appears normal
asthenozoospermia ( J:350937 )
• straight line velocity, curvilinear velocity, and average path velocity of spermatozoa are reduced after 10 minutes of incubation in a capacitation medium
• however, the percentage of motile spermatozoa is comparable to wild-type
reduced male fertility ( J:350937 )
• males are subfertile
• in the presence of cumulus cells and intact zona pellucida, the in vitro fertilization rate of spermatozoa is decreased
• in the absence of cumulus cells, in vitro fertilization rate of spermatozoa is decreased
• however, the decreased fertilization rate of spermatozoa is rescued by removing both cumulus cells and zona pellucida
impaired sperm penetration of zona pellucida ( J:350937 )
• the decreased fertilization rate of spermatozoa is rescued by removing both cumulus cells and zona pellucida, indicating that zona pellucida penetration is impaired

cellular
abnormal sperm head morphology ( J:350937 )
• 47% of sperm heads exhibit bluntness in the hook regions
• however, the acrosome appears normal
asthenozoospermia ( J:350937 )
• straight line velocity, curvilinear velocity, and average path velocity of spermatozoa are reduced after 10 minutes of incubation in a capacitation medium
• however, the percentage of motile spermatozoa is comparable to wild-type




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory