Phenotypes associated with this allele

• Allele Symbol: Slc44a4^tm1.2Said
• Allele Name: targeted mutation 1.2, Hamid M Said
• Allele ID: MGI:7703492
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc44a4^tm1.2Said/Slc44a4^tm1.2Said	involves: BALB/cJ * C57BL/6J * C57BL/6N	MGI:7703505

Genotype
MGI:7703505

hm1

• Allelic Composition: Slc44a4^tm1.2Said/Slc44a4^tm1.2Said
• Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:351314 )

digestive/alimentary system

decreased colon length ( J:351314 )

• significantly shorter but not significant abnormalities in the tissue

abnormal vitamin absorption ( J:351314 )

• uptake of thiamine pyrophosphate by colonic sheets is almost completely inhibited

• however, uptake of free [3H]thiamine is similar to controls

increased susceptibility to induced colitis ( J:351314 )

• increased signs of disease activity following exposure to 1.5% DSS compared to similarly treated wild-type controls

immune system

increased susceptibility to induced colitis ( J:351314 )

• increased signs of disease activity following exposure to 1.5% DSS compared to similarly treated wild-type controls

homeostasis/metabolism

abnormal vitamin absorption ( J:351314 )

• uptake of thiamine pyrophosphate by colonic sheets is almost completely inhibited

• however, uptake of free [3H]thiamine is similar to controls