Phenotypes associated with this allele

• Allele Symbol: Slitrk4^tm1.1Jaru
• Allele Name: targeted mutation 1.1, Jun Aruga
• Allele ID: MGI:7703964
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slitrk4^tm1.1Jaru/Slitrk4^tm1.1Jaru	B6.129P2-Slitrk4^tm1.1Jaru	MGI:7703968
ot2	Slitrk4^tm1.1Jaru/Y	B6.129P2-Slitrk4^tm1.1Jaru	MGI:7703969

Genotype
MGI:7703968

hm1

• Allelic Composition: Slitrk4^tm1.1Jaru/Slitrk4^tm1.1Jaru
• Genetic Background: B6.129P2-Slitrk4^tm1.1Jaru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:348363 )

♀ • viable and fertile, only makes were used for behavioral studies

Genotype
MGI:7703969

ot2

• Allelic Composition: Slitrk4^tm1.1Jaru/Y
• Genetic Background: B6.129P2-Slitrk4^tm1.1Jaru

behavior/neurological

behavior/neurological phenotype ( J:348363 )

♂N • no difference in anxiety related responses

enhanced cued conditioning behavior ( J:348363 )

♂ • increased freezing after the second conditioned stimulus (CS)- unconditioned stimulus (US) stimulus and after exposure to the CS in the cued test

♂ • in a fear memory extinction profile freezing is increased on day 2 but not day 3 compared to wild-type mice

decreased exploration in new environment ( J:348363 )

♂ • decreased distance traveled in an open field test, social discrimination test, and light-dark box test

♂ • however, locomotion in home cages is similar to controls

♂ • increased immobility time in forced swimming test during the first 30s

abnormal olfactory behavior ( J:348363 )

♂ • in a buried food seeking test find the buried cookie more quickly suggesting elevated olfactory function

decreased aggression towards mice ( J:348363 )

♂ • in a resident-intruder assay show reduced attacking behavior and increased hiding behavior

decreased social investigation ( J:348363 )

♂ • spend more time alone in a novel environment with an unfamiliar male mouse

nervous system

abnormal brain interneuron morphology ( J:348363 )

♂ • decrease in the calretinin-positive GABAergic interneuron subset in the amygdala

♂ • the ability of cultured ES cells to differentiate into calretinin-positive neurons is impaired

abnormal amygdala morphology ( J:348363 )

♂ • decrease in the calretinin-positive GABAergic interneuron subset in the amygdala

abnormal neuron physiology ( J:348363 )

♂ • hyperpolarization after four pulses of 100 Hz is reduced compared to wild-type controls suggesting impaired feedback-type inhibition

abnormal synaptic plasticity ( J:348363 )

♂ • altered plasticity in the amygdala lateral nucleus

enhanced long-term potentiation ( J:348363 )

♂ • increased long term potentiation in the absence of the GABA receptor non-competitive antagonist picrotoxin

♂ • however LTP is comparable to wild-type in presence of 100uM picrotoxin

decreased prepulse inhibition ( J:348363 )

♂ • prepulse inhibition in the auditory startle response tends to be reduced without clear differences in auditory function