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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb21em1Jhan
endonuclease-mediated mutation 1, Jiahuai Han
MGI:7705190
Summary 2 genotypes


Genotype
MGI:7705532
hm1
Allelic
Composition		 Zbtb21em1Jhan/Zbtb21em1Jhan
Genetic
Background		 C57BL/6J-Zbtb21em1Jhan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb21em1Jhan mutation (0 available); any Zbtb21 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:351206 )
N
• mice show little to no cognitive deficits, with mice having normal learning and memory in the Morris water maze

nervous system
nervous system phenotype ( J:351206 )
N
• mice show little to no synaptic deficits, with mice having normal basal synaptic transmission and long-term potentiation (LTP), and normal hippocampus and cortex thickness

growth/size/body
growth/size/body region phenotype ( J:351206 )
N
• normal fetal size at E15.5




Genotype
MGI:7705525
cx2
Allelic
Composition		 Dp(16Lipi-Zbtb21)1Yey/Zbtb21em1Jhan
Genetic
Background		 B6.Cg-Dp(16Lipi-Zbtb21)1Yey Zbtb21em1Jhan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(16Lipi-Zbtb21)1Yey mutation (3 available); any Dp(16Lipi-Zbtb21)1Yey mutation (3 available)
Zbtb21em1Jhan mutation (0 available); any Zbtb21 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:351206 )
N
• the synaptic deficits seen in Dp(16Lipi-Zbtb21)1Yey/0 mice are largely restored, with corrected LTP, basal synaptic transmission, frequency of spontaneous excitatory postsynaptic current (sEPSCs), and dendritic spine density in the hippocampus and mice show no differences in cortical thickness or the area of the hippocampus
abnormal inhibitory postsynaptic currents ( J:351206 )
• mice exhibit abnormal frequency of spontaneous inhibitory postsynaptic current (sIPSCs) in the hippocampal CA1 pyramidal neurons

behavior/neurological
behavior/neurological phenotype ( J:351206 )
N
• cognitive deficits seen in Dp(16Lipi-Zbtb21)1Yey/0 mice are largely restored, with mice showing normal learning and memory in the Morris water maze




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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory