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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sorem1(CAG-Zbtb21,-GFP)Jhan
endonuclease-mediated mutation 1, Jiahuai Han
MGI:7705191
Summary 3 genotypes


Genotype
MGI:7705529
cn1
Allelic
Composition		 Gt(ROSA)26Sorem1(CAG-Zbtb21,-GFP)Jhan/Gt(ROSA)26Sor+
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background		 B6.Cg-Gt(ROSA)26Sorem1(CAG-Zbtb21,-GFP)Jhan Tg(Camk2a-cre)T29-1Stl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem1(CAG-Zbtb21,-GFP)Jhan mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired spatial learning ( J:351206 )
• mice show longer latency to find the target during the Morris water maze training on day 4
abnormal spatial reference memory ( J:351206 )
• in the Morris water maze probe test, mice spend less time in the target quadrant

nervous system
decreased dendritic spine density ( J:351206 )
• mice show a reduction in spine density in the hippocampus
abnormal CNS synaptic transmission ( J:351206 )
• mice show reduced basal synaptic transmission in hippocampal CA1 region
abnormal excitatory postsynaptic potential ( J:351206 )
• mice exhibit reduced fEPSP amplitude in hippocampal CA1 region
reduced long-term potentiation ( J:351206 )
• mice show compromised LTP, with reduced fEPSP amplitude in hippocampal CA1 region




Genotype
MGI:7705527
cn2
Allelic
Composition		 Gt(ROSA)26Sorem1(CAG-Zbtb21,-GFP)Jhan/Gt(ROSA)26Sor+
Tg(Nes-cre)1Kln/0
Genetic
Background		 B6.Cg-Gt(ROSA)26Sorem1(CAG-Zbtb21,-GFP)Jhan Tg(Nes-cre)1Kln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem1(CAG-Zbtb21,-GFP)Jhan mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired contextual conditioning behavior ( J:351206 )
• mice show reduced freezing time during the contextual part of the fear conditioning test
impaired spatial learning ( J:351206 )
• mice show longer latency to find the target during the Morris water maze training on day 4
abnormal spatial reference memory ( J:351206 )
• in the Morris water maze probe test, mice spend less time in the target quadrant

nervous system
decreased dendritic spine density ( J:351206 )
• mice show a reduction in spine density in the hippocampus
abnormal postsynaptic density morphology ( J:351206 )
• mice show a reduction in post synaptic density in hippocampal CA1
abnormal CNS synaptic transmission ( J:351206 )
• mice show reduced basal synaptic transmission in hippocampal CA1 region
abnormal excitatory postsynaptic potential ( J:351206 )
• mice exhibit reduced fEPSP amplitude in hippocampal CA1 region
reduced long-term potentiation ( J:351206 )
• mice show compromised LTP, with reduced fEPSP amplitude in hippocampal CA1 region




Genotype
MGI:7705530
cn3
Allelic
Composition		 Gt(ROSA)26Sorem1(CAG-Zbtb21,-GFP)Jhan/Gt(ROSA)26Sor+
Aldh1l1em1(cre/ERT2)Nju/Aldh1l1+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1l1em1(cre/ERT2)Nju mutation (0 available); any Aldh1l1 mutation (58 available)
Gt(ROSA)26Sorem1(CAG-Zbtb21,-GFP)Jhan mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:351206 )
N
• although tamoxifen-treated mice show trends towards changes in the Morris Water maze, they are not significant

nervous system
nervous system phenotype ( J:351206 )
N
• although tamoxifen-treated mice show trends towards changes in long-term potentiation (LTP) recordings, they are not significant




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory