About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Akap4em1Bbw
endonuclease-mediated mutation 1, Binbin Wang
MGI:7707395
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
Akap4em1Bbw/Y C57BL/6J-Akap4em1Bbw MGI:7707404


Genotype
MGI:7707404
ot1
Allelic
Composition
Akap4em1Bbw/Y
Genetic
Background
C57BL/6J-Akap4em1Bbw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap4em1Bbw mutation (0 available); any Akap4 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• sperm with attenuated principal piece
• however, no obvious abnormalities in manchette structure of spermatids
• 54% of sperm show fiber sheath abnormalities in the flagella
• the fibrous sheath is either unrecognizable or partially lost
• approximately 25% of sperm exhibit bent tails
• approximately 33% of sperm exhibit short tails
• mice exhibit diminished sperm count
• males exhibit severe subfertility, with only 8/24 females mated with mutant males becoming pregnant

cellular
• sperm with attenuated principal piece
• however, no obvious abnormalities in manchette structure of spermatids
• 54% of sperm show fiber sheath abnormalities in the flagella
• the fibrous sheath is either unrecognizable or partially lost
• approximately 25% of sperm exhibit bent tails
• approximately 33% of sperm exhibit short tails
• mice exhibit diminished sperm count





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory