Phenotypes associated with this allele

• Allele Symbol: Akap4^em1Bbw
• Allele Name: endonuclease-mediated mutation 1, Binbin Wang
• Allele ID: MGI:7707395
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Akap4^em1Bbw/Y	C57BL/6J-Akap4^em1Bbw	MGI:7707404

Genotype
MGI:7707404

ot1

• Allelic Composition: Akap4^em1Bbw/Y
• Genetic Background: C57BL/6J-Akap4^em1Bbw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm principal piece morphology ( J:352416 )

♂ • sperm with attenuated principal piece

♂ • however, no obvious abnormalities in manchette structure of spermatids

abnormal sperm fibrous sheath morphology ( J:352416 )

♂ • 54% of sperm show fiber sheath abnormalities in the flagella

♂ • the fibrous sheath is either unrecognizable or partially lost

kinked sperm flagellum ( J:352416 )

♂ • approximately 25% of sperm exhibit bent tails

short sperm flagellum ( J:352416 )

♂ • approximately 33% of sperm exhibit short tails

oligozoospermia ( J:352416 )

♂ • mice exhibit diminished sperm count

decreased sperm progressive motility ( J:352416 )

♂

reduced male fertility ( J:352416 )

♂ • males exhibit severe subfertility, with only 8/24 females mated with mutant males becoming pregnant

cellular

abnormal sperm principal piece morphology ( J:352416 )

♂ • however, no obvious abnormalities in manchette structure of spermatids

♂ • sperm with attenuated principal piece

abnormal sperm fibrous sheath morphology ( J:352416 )

♂ • 54% of sperm show fiber sheath abnormalities in the flagella

♂ • the fibrous sheath is either unrecognizable or partially lost

kinked sperm flagellum ( J:352416 )

♂ • approximately 25% of sperm exhibit bent tails

short sperm flagellum ( J:352416 )

♂ • approximately 33% of sperm exhibit short tails

oligozoospermia ( J:352416 )

♂ • mice exhibit diminished sperm count

decreased sperm progressive motility ( J:352416 )

♂