Phenotypes associated with this allele

• Allele Symbol: Stk32a^em1Mdea
• Allele Name: endonuclease-mediated mutation 1, Michael R Deans
• Allele ID: MGI:7707448
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk32a^em1Mdea/Stk32a^em1Mdea	involves: 129S1/SvImJ * C57BL/6J * CBA/J	MGI:7707714

Genotype
MGI:7707714

hm1

• Allelic Composition: Stk32a^em1Mdea/Stk32a^em1Mdea
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal vestibular hair cell morphology ( J:338146 )

• planar polarized organization of vestibular hair cells in the medial regions of the utricle is severely disrupted

• however, auditory hair cells in the cochleae are not impacted

• however, the intrinsic polarity of the majority of vestibular hair cells remains intact

abnormal vestibular hair cell stereociliary bundle morphology ( J:338146 )

• the bundles of hair cells in the striolar and medial extrastriolar regions of the utricle are randomly oriented relative to each other while lateral hair cells remain correctly oriented

• misoriented bundles are also seen in the outer region of the saccule and within the semi-circular canal cristae

• bundle orientation is disorganized rather than reversed and the extent of misorientation is greater in the maculae than in the cristae

nervous system

abnormal vestibular hair cell morphology ( J:338146 )

• planar polarized organization of vestibular hair cells in the medial regions of the utricle is severely disrupted

• however, auditory hair cells in the cochleae are not impacted

• however, the intrinsic polarity of the majority of vestibular hair cells remains intact

abnormal vestibular hair cell stereociliary bundle morphology ( J:338146 )

• the bundles of hair cells in the striolar and medial extrastriolar regions of the utricle are randomly oriented relative to each other while lateral hair cells remain correctly oriented

• misoriented bundles are also seen in the outer region of the saccule and within the semi-circular canal cristae

• bundle orientation is disorganized rather than reversed and the extent of misorientation is greater in the maculae than in the cristae

behavior/neurological

behavior/neurological phenotype ( J:338146 )

N • mice show no over physical or behavioral abnormalities