Phenotypes associated with this allele

• Allele Symbol: Tecrl^em1Bcgen
• Allele Name: Tecrl
• Allele ID: MGI:7707933
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tecrl^em1Bcgen/Tecrl^em1Bcgen	C57BL/6-Tecrl^em1Bcgen	MGI:7707935

Genotype
MGI:7707935

hm1

• Allelic Composition: Tecrl^em1Bcgen/Tecrl^em1Bcgen
• Genetic Background: C57BL/6-Tecrl^em1Bcgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber mitochondrial morphology ( J:325991 )

• hearts exhibit mitochondria changes, including irregular arrangement and loss of cristae

• mitochondrial cross-sectional area and the percentage of mitochondria with disorganized cristae ultrastructure are increased in hearts

decreased heart left ventricle muscle contractility ( J:325991 )

• 8-week-old mice exhibit decreased left ventricular ejection fraction and fractional shortening

abnormal heart echocardiography feature ( J:325991 )

• echocardiography on 8-week-old, but not 4- to 5-week-old, mice shows decreased left ventricular ejection fraction, increased left ventricular internal dimension systole, increased left ventricular internal dimension diastole, increased left ventricular end-systolic volume, and increased left ventricular end-diastolic volume

ventricular tachycardia ( J:325991 )

• ventricular tachycardia is seen immediately after an epinephrine and caffeine injection

• 60% of mice show ventricular tachycardia sustained for 1 to 5 seconds, 40% of them sustained for 5 to 15 seconds, and 30% of them sustained longer than 15 seconds

ventricular premature beat ( J:325991 )

• multiple premature ventricular beats are seen immediately after an epinephrine and caffeine injection

cellular

abnormal myocardial fiber mitochondrial morphology ( J:325991 )

• hearts exhibit mitochondria changes, including irregular arrangement and loss of cristae

• mitochondrial cross-sectional area and the percentage of mitochondria with disorganized cristae ultrastructure are increased in hearts

abnormal cellular respiration ( J:325991 )

• adult cardiomyocytes exhibit a decrease in mitochondrial basal respiration and ATP production

oxidative stress ( J:325991 )

• 8-week-old hearts show an increase in reactive oxygen species (ROS) production

• primary neonatal cardiomyocytes exhibit increased ROS levels

• however, 4-5 month old cardiomyocytes show normal ROS levels

muscle

abnormal myocardial fiber mitochondrial morphology ( J:325991 )

• hearts exhibit mitochondria changes, including irregular arrangement and loss of cristae

• mitochondrial cross-sectional area and the percentage of mitochondria with disorganized cristae ultrastructure are increased in hearts

decreased heart left ventricle muscle contractility ( J:325991 )

• 8-week-old mice exhibit decreased left ventricular ejection fraction and fractional shortening