Phenotypes associated with this allele

• Allele Symbol: Vamp4^em1Tax
• Allele Name: endonuclease-mediated mutation 1, Tao Xu
• Allele ID: MGI:7708019
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vamp4^em1Tax/Vamp4^em1Tax	involves: C57BL/6J	MGI:7709109

Genotype
MGI:7709109

hm1

• Allelic Composition: Vamp4^em1Tax/Vamp4^em1Tax
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:352764 )

N • normal pancreas morphology with a similar distribution and density of islets compared to controls

N • morphology and distribution of alpha and beta cells are similar to wild-type controls

abnormal pancreatic beta cell morphology ( J:352764 )

• increase in the number and density of insulin secretory granules

abnormal pancreatic beta cell physiology ( J:352764 )

• decrease in the number and density of insulin secretory granule-lysosome interactions and the ratio of insulin secretory granule-lysosomes to total insulin secretory granules s reduced in beta cells

increased insulin secretion ( J:352764 )

• increase in mean insulin level

• however, glucagon levels are similar to wild-type controls

• in isolated primary beta cells levels of insulin and proinsulin are increased by 23% and 14%, respectively

homeostasis/metabolism

increased insulin secretion ( J:352764 )

• increase in mean insulin level

• however, glucagon levels are similar to wild-type controls

• in isolated primary beta cells levels of insulin and proinsulin are increased by 23% and 14%, respectively

improved glucose tolerance ( J:352764 )

♂ • in males at 15 min after high glucose stimulation

♂ • however, performance in an insulin tolerance test is similar to wild-type controls