Phenotypes associated with this allele

• Allele Symbol: Zup1^em1Lisi
• Allele Name: endonuclease-mediated mutation 1, Siji Li
• Allele ID: MGI:7709433
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zup1^em1Lisi/Zup1^em1Lisi	involves: C57BL/6J	MGI:7709437

Genotype
MGI:7709437

hm1

• Allelic Composition: Zup1^em1Lisi/Zup1^em1Lisi
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:350802 )

• increased susceptibility to intravenous infection with vesicular stomatitis virus (VSV) with higher viral titers in the blood and brain and lower expression levels of some IFN-stimulated genes

• however, susceptibility to intravenous infection with herpes simplex type 1 (HSV-1) virus is similar to controls

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:350802 )

• increased mortality following intranasal influenza A infection

immune system

abnormal macrophage physiology ( J:350802 )

• bone marrow derived and peritoneal macrophages infected with VSV show reduced expression of Ifnb1 and Isg15

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:350802 )

• increased susceptibility to intravenous infection with vesicular stomatitis virus (VSV) with higher viral titers in the blood and brain and lower expression levels of some IFN-stimulated genes

• however, susceptibility to intravenous infection with herpes simplex type 1 (HSV-1) virus is similar to controls

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:350802 )

• increased mortality following intranasal influenza A infection

hematopoietic system

abnormal macrophage physiology ( J:350802 )

• bone marrow derived and peritoneal macrophages infected with VSV show reduced expression of Ifnb1 and Isg15