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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hsf5em1Asla
endonuclease-mediated mutation 1, Muhammad Asla
MGI:7709565
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hsf5em1Asla/Hsf5em1Asla Not Specified MGI:7709786


Genotype
MGI:7709786
hm1
Allelic
Composition		 Hsf5em1Asla/Hsf5em1Asla
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf5em1Asla mutation (0 available); any Hsf5 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:352587 )
• severe depletion of pachytene spermatocytes during meiosis leading to azoospermia in epididymal tail
abnormal male meiosis ( J:352587 )
• aberrant sex chromosome remodeling and silencing in spermatocytes, with X-Y chromosomes remaining elongated rather than forming into compacted XY body
increased male germ cell apoptosis ( J:352587 )
• spermatocytes undergo massive apoptosis
decreased testis weight ( J:352587 )
• testes weigh approximately 80% less than control testes
arrest of spermatogenesis ( J:352587 )
• spermatogenesis is blocked during meiosis, with absent post-meiotic germ cells and the most advanced germ cells in the seminiferous tubules being pachytene spermatocytes
arrest of male meiosis ( J:352587 )
• pachytene meiosis arrest with sex chromosome defects
male infertility ( J:352587 )
• males mated with wild-type or heterozygous females do not produce offspring indicating male infertility

endocrine/exocrine glands
decreased testis weight ( J:352587 )
• testes weigh approximately 80% less than control testes

cellular
azoospermia ( J:352587 )
• severe depletion of pachytene spermatocytes during meiosis leading to azoospermia in epididymal tail
abnormal male meiosis ( J:352587 )
• aberrant sex chromosome remodeling and silencing in spermatocytes, with X-Y chromosomes remaining elongated rather than forming into compacted XY body
arrest of male meiosis ( J:352587 )
• pachytene meiosis arrest with sex chromosome defects
increased male germ cell apoptosis ( J:352587 )
• spermatocytes undergo massive apoptosis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory