mortality/aging
• mice intraperitoneally injected with Listeria monocytogens show shortened survival than controls
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• mice intraperitoneally injected with the DNA virus herpes simplex virus-1 (HSV-1) show shortened survival than controls
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• mice intraperitoneally injected with the RNA virus vesicular stomatitis virus (VSV) show shortened survival than controls
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immune system
• production of IFN-beta in bone marrow derived macrophages (BMDMs) is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists
• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production of IFN-beta
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• serum levels of IFN beta are decreased in mice intraperitoneally injected with VSV, Listeria monocytogens or HSV-1
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• production of IL-6 in BMDMs is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists
• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production of IL-6
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• serum levels of IL-6 are decreased in mice intraperitoneally injected with VSV, Listeria monocytogens or HSV-1
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• production of TNF in BMDMs is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists
• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production TNF
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• mice show impaired innate antiviral defense to VSV, Listeria monocytogens, and HSV-1 infection
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• mice show increased microbe titers in the spleen and liver following intraperitoneal injection with Listeria monocytogens, with decreased survival and decreased serum levels of cytokines IL-6 and IFN-beta
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• mice intraperitoneally injected with Listeria monocytogens show shortened survival than controls
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• mice show increased microbe titers in the spleen and liver following intraperitoneal injection with the DNA virus herpes simplex virus-1 (HSV-1)
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• mice intraperitoneally injected with the DNA virus herpes simplex virus-1 (HSV-1) show shortened survival than controls
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• mice show increased microbe titers in the spleen and liver following intraperitoneal injection with the RNA virus vesicular stomatitis virus (VSV)
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• mice intraperitoneally injected with the RNA virus vesicular stomatitis virus (VSV) show shortened survival than controls
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homeostasis/metabolism
• production of IFN-beta in bone marrow derived macrophages (BMDMs) is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists
• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production of IFN-beta
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• serum levels of IFN beta are decreased in mice intraperitoneally injected with VSV, Listeria monocytogens or HSV-1
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• production of IL-6 in BMDMs is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists
• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production of IL-6
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• serum levels of IL-6 are decreased in mice intraperitoneally injected with VSV, Listeria monocytogens or HSV-1
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• production of TNF in BMDMs is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists
• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production TNF
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