Phenotypes associated with this allele

• Allele Symbol: Trim41^tm1Caox
• Allele Name: targeted mutation 1, Xuetao Cao
• Allele ID: MGI:7709890
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim41^tm1Caox/Trim41^tm1Caox	B6.Cg-Trim41^tm1Caox	MGI:7709892

Genotype
MGI:7709892

hm1

• Allelic Composition: Trim41^tm1Caox/Trim41^tm1Caox
• Genetic Background: B6.Cg-Trim41^tm1Caox

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:340065 )

• mice intraperitoneally injected with Listeria monocytogens show shortened survival than controls

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:340065 )

• mice intraperitoneally injected with the DNA virus herpes simplex virus-1 (HSV-1) show shortened survival than controls

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:340065 )

• mice intraperitoneally injected with the RNA virus vesicular stomatitis virus (VSV) show shortened survival than controls

immune system

decreased interferon level ( J:340065 )

• production of IFN-beta in bone marrow derived macrophages (BMDMs) is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists

• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production of IFN-beta

decreased circulating interferon-beta level ( J:340065 )

• serum levels of IFN beta are decreased in mice intraperitoneally injected with VSV, Listeria monocytogens or HSV-1

decreased interleukin level ( J:340065 )

• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production of IL-6

• production of IL-6 in BMDMs is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists

decreased circulating interleukin-6 level ( J:340065 )

• serum levels of IL-6 are decreased in mice intraperitoneally injected with VSV, Listeria monocytogens or HSV-1

abnormal tumor necrosis factor level ( J:340065 )

• production of TNF in BMDMs is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists

• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production TNF

abnormal innate immunity ( J:340065 )

• mice show impaired innate antiviral defense to VSV, Listeria monocytogens, and HSV-1 infection

increased susceptibility to bacterial infection ( J:340065 )

• mice show increased microbe titers in the spleen and liver following intraperitoneal injection with Listeria monocytogens, with decreased survival and decreased serum levels of cytokines IL-6 and IFN-beta

increased susceptibility to bacterial infection induced morbidity/mortality ( J:340065 )

• mice intraperitoneally injected with Listeria monocytogens show shortened survival than controls

increased susceptibility to Herpesvirales infection ( J:340065 )

• mice show increased microbe titers in the spleen and liver following intraperitoneal injection with the DNA virus herpes simplex virus-1 (HSV-1) , with decreased survival, decreased serum levels of cytokines IL-6 and IFN-beta, and enhanced replication of HSV-1 in the brain

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:340065 )

• mice intraperitoneally injected with the DNA virus herpes simplex virus-1 (HSV-1) show shortened survival than controls

increased susceptibility to Riboviria infection ( J:340065 )

• mice show increased microbe titers in the spleen and liver following intraperitoneal injection with the RNA virus vesicular stomatitis virus (VSV) , decreased survival, and decreased serum levels of cytokines IL-6 and IFN-beta

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:340065 )

• mice intraperitoneally injected with the RNA virus vesicular stomatitis virus (VSV) show shortened survival than controls

homeostasis/metabolism

decreased interferon level ( J:340065 )

• production of IFN-beta in bone marrow derived macrophages (BMDMs) is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists

• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production of IFN-beta

decreased circulating interferon-beta level ( J:340065 )

• serum levels of IFN beta are decreased in mice intraperitoneally injected with VSV, Listeria monocytogens or HSV-1

decreased interleukin level ( J:340065 )

• production of IL-6 in BMDMs is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists

• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production of IL-6

decreased circulating interleukin-6 level ( J:340065 )

• serum levels of IL-6 are decreased in mice intraperitoneally injected with VSV, Listeria monocytogens or HSV-1

abnormal tumor necrosis factor level ( J:340065 )

• production of TNF in BMDMs is reduced after treatments with either cytosolic RNA sensor agonists or cytosolic DNA sensor agonists

• BMDMs infected with RNA viruses, VSV and Sendai virus, and DNA viruses, HSV-1 and Vaccina virus, show reduced pathogen-induced production TNF