Phenotypes associated with this allele

• Allele Symbol: Adam29^em1Otin
• Allele Name: endonuclease-mediated mutation 1, Carlos Lopez-Otin
• Allele ID: MGI:7710881
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam29^em1Otin/Adam29^em1Otin	C57BL/6-Adam29^em1Otin	MGI:7710883

Genotype
MGI:7710883

hm1

• Allelic Composition: Adam29^em1Otin/Adam29^em1Otin
• Genetic Background: C57BL/6-Adam29^em1Otin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:353244 )

N • mice show normal growth and development

decreased susceptibility to diet-induced obesity ( J:353244 )

♂ • male mice fed a high-fat diet show a lower rate of body weight increase compared to wild-type mice

♂ • however, high-fat fed mice show no differences in liver, spleen, or gonadal white adipose tissue weight, in glucose homeostasis, in plasma levels of adiponectin and leptin, or in other parameters associated with liver, kidney, and pancreatic function

homeostasis/metabolism

decreased circulating phosphate level ( J:353244 )

♂ • mice fed a high-fat diet exhibit reduced plasma phosphorus level

increased energy expenditure ( J:353244 )

♂ • males show elevated energy expenditure

♂ • however, no differences in heat production or locomotor activity are seen

decreased susceptibility to diet-induced obesity ( J:353244 )

♂ • male mice fed a high-fat diet show a lower rate of body weight increase compared to wild-type mice

♂ • however, high-fat fed mice show no differences in liver, spleen, or gonadal white adipose tissue weight, in glucose homeostasis, in plasma levels of adiponectin and leptin, or in other parameters associated with liver, kidney, and pancreatic function

increased carbon dioxide production ( J:353244 )

♂ • males show elevated carbon dioxide production

increased oxygen consumption ( J:353244 )

♂ • males show elevated oxygen consumption

increased respiratory quotient ( J:353244 )

♂ • respiratory exchange ratio tends to be slightly increased in males, especially during daytime

♂ • mice exhibit a rightward shift in the respiratory exchange ratio distribution, even when kept on a high-fat diet, which may indicate a higher metabolic flexibility toward carbohydrate oxidation

enhanced wound healing ( J:353244 )

• mice show accelerated wound healing, with 75% wound closure seen on day 4 post-incision compared to wild-type mice which show this level of wound closure on day 7 and a wound closure of 30.33% compared to 7.34% in controls at 5 hours post-injury

• however, in an in vitro scratch assay, mouse embryonic fibroblasts do not show any differences from wild-type mice in scratch closure

immune system

increased inflammatory response ( J:353244 )

♂ • male mice fed a high-fat diet show higher incidence of inflammation

liver/biliary system

abnormal hepatocyte morphology ( J:353244 )

♂ • male mice fed a high-fat diet show reduced hepatocyte hypertrophy

decreased susceptibility to diet-induced hepatic steatosis ( J:353244 )

♂ • males fed a high-fat diet show reduced incidence of microvacuolar steatosis and show lower histological scores for non-alcoholic liver disease

reproductive system

reproductive system phenotype ( J:353244 )

N • mice exhibit normal fertility