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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zdhhc20em1Jdo
endonuclease-mediated mutation 1, Julian Downward
MGI:7711187
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Zdhhc20em1Jdo/Zdhhc20em1Jdo
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:7711290


Genotype
MGI:7711290
cn1
Allelic
Composition		 Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Zdhhc20em1Jdo/Zdhhc20em1Jdo
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm2Tyj mutation (4 available); any Trp53 mutation (240 available)
Zdhhc20em1Jdo mutation (0 available); any Zdhhc20 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:348743 )
N
• survival is similar to mutant mice wild-type for Zdhhc20

neoplasm
decreased metastatic potential ( J:348743 )
• liver metastases are found in 40% of mice compared to 93% of mutant mice wild-type for Zdhhc20
• a similar trend is seen for lung metastases
• both total liver lesion area and number are profoundly reduced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory