Phenotypes associated with this allele

• Allele Symbol: Lrriq1^em1Ysato
• Allele Name: endonuclease-mediated mutation 1, Youichi Sato
• Allele ID: MGI:7711345
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrriq1^em1Ysato/Lrriq1^em1Ysato	C57BL/6N-Lrriq1^em1Ysato	MGI:7711347

Genotype
MGI:7711347

hm1

• Allelic Composition: Lrriq1^em1Ysato/Lrriq1^em1Ysato
• Genetic Background: C57BL/6N-Lrriq1^em1Ysato

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased male germ cell apoptosis ( J:338085 )

♂ • numerous apoptosis-positive cells are seen in the testis indicating testicular germ cell apoptosis

♂ • several apoptotic sperm are detected in the cauda epididymis

asthenozoospermia ( J:338085 )

♂ • sperm motility is reduced

♂ • however, no difference is seen in sperm number, testis size or weight, or morphology of testis, cauda epididymis or sperm

reduced male fertility ( J:338085 )

♂ • the litter size from matings of homozygous males to wild-type females is reduced indicating reduced male fertility

♂ • however, female fertility is unaffected

cellular

increased male germ cell apoptosis ( J:338085 )

♂ • numerous apoptosis-positive cells are seen in the testis indicating testicular germ cell apoptosis

♂ • several apoptotic sperm are detected in the cauda epididymis

asthenozoospermia ( J:338085 )

♂ • sperm motility is reduced

♂ • however, no difference is seen in sperm number, testis size or weight, or morphology of testis, cauda epididymis or sperm