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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gpr75em1Tes
endonuclease-mediated mutation 1, Lino Tessarollo
MGI:7711515
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gpr75em1Tes/Gpr75em1Tes involves: C57BL/6J * C57BL/6N * C57BL/6NCr * DBA/2J MGI:7711541


Genotype
MGI:7711541
hm1
Allelic
Composition
Gpr75em1Tes/Gpr75em1Tes
Genetic
Background
involves: C57BL/6J * C57BL/6N * C57BL/6NCr * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr75em1Tes mutation (0 available); any Gpr75 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 26-week-old males, but not females, are resistant to age-related gain in body mass

behavior/neurological
• mice are impaired on a trace fear conditioning task, showing reduced freezing within the trace period after conditioning indicating reduced trace memory
• mice show reduced freezing behavior when reintroduced into context, indicating impaired contextual memory
• mice exhibit increased anxiety-like behaviors, with mice spending less time in the open arms of the elevated plus maze and have fewer entries to these arms
• however, no difference in total exploration activity is seen





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory