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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cfdp1tm2.1Dkwpd
targeted mutation 2.1, Thomas Diekwisch
MGI:7711522
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cfdp1tm1Dkwpd/Cfdp1tm2.1Dkwpd
E2f1Tg(Wnt1-cre)2Sor/E2f1+ 		involves: 129 * 129S2/SvPas * C3H * C57BL/6 MGI:7711575
cn2
 		Anp32etm1Mak/Anp32etm1Mak
Cfdp1tm1Dkwpd/Cfdp1tm2.1Dkwpd
E2f1Tg(Wnt1-cre)2Sor/E2f1+ 		involves: 129 * C3H * C57BL/6 MGI:7711577


Genotype
MGI:7711575
cn1
Allelic
Composition		 Cfdp1tm1Dkwpd/Cfdp1tm2.1Dkwpd
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic
Background		 involves: 129 * 129S2/SvPas * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfdp1tm1Dkwpd mutation (0 available); any Cfdp1 mutation (121 available)
Cfdp1tm2.1Dkwpd mutation (0 available); any Cfdp1 mutation (121 available)
E2f1Tg(Wnt1-cre)2Sor mutation (2 available); any E2f1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal craniofacial morphology ( J:349245 )
• extensive craniofacial abnormalities in the mid face region, nose, maxillary region, mandibular region, and flattened forebrain region at E16
abnormal incisor morphology ( J:349245 )
• underdeveloped with altered morphology at E16
small mandible ( J:349245 )
• small and rudimentary at E16
• consists mainly of soft tissue lacking mineralized bone at E16
flat head ( J:349245 )
• flattened forebrain region at E16

cellular
abnormal intracellular organelle physiology ( J:349245 )
• H2A.Z and RCC1 levels at the major satellite repeats are significantly decreased

growth/size/body
abnormal incisor morphology ( J:349245 )
• underdeveloped with altered morphology at E16
flat head ( J:349245 )
• flattened forebrain region at E16

skeleton
abnormal incisor morphology ( J:349245 )
• underdeveloped with altered morphology at E16
small mandible ( J:349245 )
• small and rudimentary at E16
• consists mainly of soft tissue lacking mineralized bone at E16
abnormal intramembranous bone ossification ( J:349245 )
• consists mainly of soft tissue lacking mineralized bone at E16




Genotype
MGI:7711577
cn2
Allelic
Composition		 Anp32etm1Mak/Anp32etm1Mak
Cfdp1tm1Dkwpd/Cfdp1tm2.1Dkwpd
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic
Background		 involves: 129 * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32etm1Mak mutation (1 available); any Anp32e mutation (21 available)
Cfdp1tm1Dkwpd mutation (0 available); any Cfdp1 mutation (121 available)
Cfdp1tm2.1Dkwpd mutation (0 available); any Cfdp1 mutation (121 available)
E2f1Tg(Wnt1-cre)2Sor mutation (2 available); any E2f1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal intracellular organelle physiology ( J:349245 )
N
• H2A.Z and RCC1 levels at the major satellite repeats are increased in rescue mice relative to both conditional mutant mice wild-type for Anp32e and wild-type controls

craniofacial
craniofacial phenotype ( J:349245 )
N
• loss of Anp32e expression largely rescues the craniofacial phenotype seen in conditional mutant mice wild-type for Anp32e
• maxilla and mandible are mineralized unlike in conditional mutant mice wild-type for Anp32e




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory