Phenotypes associated with this allele

• Allele Symbol: Trim41^em1Osb
• Allele Name: endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:7713327
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim41^em1Osb/Trim41^em1Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:7713339

Genotype
MGI:7713339

hm1

• Allelic Composition: Trim41^em1Osb/Trim41^em1Osb
• Genetic Background: involves: C57BL/6NJcl * DBA/2NJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:325726 )

• the number of pachytene and diplotene spermatocytes is decreased in testes

• almost no fully-matured spermatozoa are seen in the cauda epididymis

abnormal male meiosis ( J:325726 )

• XY body malformation and SYCP3 overloading in pachytene stage spermatocytes

increased male germ cell apoptosis ( J:325726 )

• TUNEL+ cells are frequently seen in the second germ cell layer of seminiferous tubules, corresponding to spermatocytes after the pachytene stage

• TUNEL signals overall are seen throughout the seminiferous epithelial cycles

small testis ( J:325726 )

male infertility ( J:325726 )

• males fail to sire pups with wild-type females

endocrine/exocrine glands

small testis ( J:325726 )

cellular

oligozoospermia ( J:325726 )

• the number of pachytene and diplotene spermatocytes is decreased in testes

• almost no fully-matured spermatozoa are seen in the cauda epididymis

abnormal male meiosis ( J:325726 )

• XY body malformation and SYCP3 overloading in pachytene stage spermatocytes

increased male germ cell apoptosis ( J:325726 )

• TUNEL+ cells are frequently seen in the second germ cell layer of seminiferous tubules, corresponding to spermatocytes after the pachytene stage

• TUNEL signals overall are seen throughout the seminiferous epithelial cycles