Phenotypes associated with this allele

• Allele Symbol: Ogt^em1Dvaa
• Allele Name: endonuclease-mediated mutation 1, Daan MF van Aalten
• Allele ID: MGI:7714705
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Ogt^em1Dvaa/Y	C57BL/6J-Ogt^em1Dvaa	MGI:7714711

Genotype
MGI:7714711

ot1

• Allelic Composition: Ogt^em1Dvaa/Y
• Genetic Background: C57BL/6J-Ogt^em1Dvaa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body fat mass ( J:353384 )

♂

increased pancreas weight ( J:353384 )

♂

increased lean body mass ( J:353384 )

♂

decreased body weight ( J:353384 )

♂

microcephaly ( J:353384 )

♂

decreased body length ( J:353384 )

♂ • decrease in nose-to-tail length

adipose tissue

decreased body fat mass ( J:353384 )

♂

craniofacial

abnormal cranium morphology ( J:353384 )

♂ • mice exhibit rounder skull

♂ • 72.2% of linear distances are shortened between 2 and 7% in the skull

decreased cranium length ( J:353384 )

♂ • reduction in skull length, while skull width is normal

♂ • along the rostro-caudal axis of the skull, 25.6% of distances are reduced, suggesting mild shortening and deformation of the skull

small cranium ( J:353384 )

♂

endocrine/exocrine glands

increased pancreas weight ( J:353384 )

♂

homeostasis/metabolism

abnormal homeostasis ( J:353384 )

♂ • mice show altered O-GlcNAcylation homeostasis with decreased global O-GlcNAcylation and reduced O-GlcNAcase and O-GlcNAc transferase protein levels in the brain

decreased circulating glucose level ( J:353384 )

♂ • mice show lower levels of glycemia

nervous system

decreased brain weight ( J:353384 )

♂ • decrease in absolute brain weight

skeleton

abnormal cranium morphology ( J:353384 )

♂ • mice exhibit rounder skull

♂ • 72.2% of linear distances are shortened between 2 and 7% in the skull

decreased cranium length ( J:353384 )

♂ • reduction in skull length, while skull width is normal

♂ • along the rostro-caudal axis of the skull, 25.6% of distances are reduced, suggesting mild shortening and deformation of the skull

small cranium ( J:353384 )

♂

mortality/aging

mortality/aging ( J:353384 )

♂N • mice are viable

reproductive system

reproductive system phenotype ( J:353384 )

♂N • normal fertility

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital disorder of glycosylation		DOID:5212		J:353384